There are no validated animal-free replacement methods to assess repeated dose toxicity. This poses problems for developing new compounds across various sectors, mainly cosmetics, where animal testing is banned in the EU. Since biological responses in animals cannot be reflected using single non-animal methods, it is necessary to combine these into Integrated Approaches to Testing and Assessment (IATA) relying on an integrated analysis of existing information coupled with the generation of new information using non-testing (grouping, read-across) and testing (in vitro) methods. This study aims to develop an easy-to-use, semantic technology-based knowledgebase (KB) in which existing safety data of cosmetic ingredients is gathered and maintained assisting non-animal systemic toxicity assessment. First data set to create the KB, 93 opinions (pdf) issued by the Scientific Committee on Consumer Safety (SCCS) between 2008-2019 dealing with 88 ingredients are processed and the information is stored in Excel files. These are converted automatically into RDF (Resource Description Framework) format. For the data scheme of the KB, officially adopted OECD testing guidelines have been profiled for acute, repeated dose toxicity, and toxicokinetics & skin absorption endpoints. SMILES is included for machine-readable purposes and Klimisch scores evaluating the reliability of the studies. When needed, expert opinions are consulted to ensure the accuracy of the observed effects in laboratory animals. To date, 76 of the 88 cosmetic ingredients, have been processed into Excel files. The results are used to improve the structure of the KB and the further automatic conversion of the remaining ≈520 opinions (1998-2021) to complete the KB. The KB is developed to facilitate the search for existing information on cosmetic ingredients, including, e.g., in vivo indications of organ and systemic toxicity. When completed, it will serve for setting up hypothesis-driven case studies on the use of IATAs for systemic toxicity assessment of cosmetic ingredients.
Originele taal-2English
StatusPublished - 30 nov 2022
Evenement 21st International Congress of the European Society of Toxicology In Vitro (ESTIV 2022) - Sitges, Spain
Duur: 21 nov 202224 nov 2022


Conference 21st International Congress of the European Society of Toxicology In Vitro (ESTIV 2022)


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