Latest developments in molecular tracers for fluorescence image-guided cancer surgery

Sophie Hernot; Labrinus van Manen; Pieterjan Debie; Jan Sven David Mieog; Alexander Lucas Vahrmeijer

doi:10.1016/S1470-2045(19)30317-1

Latest developments in molecular tracers for fluorescence image-guided cancer surgery

Sophie Hernot, Labrinus van Manen, Pieterjan Debie, Jan Sven David Mieog, Alexander Lucas Vahrmeijer

Onderzoeksoutput: Scientific review › peer review

342 Citaten (Scopus)

Samenvatting

Real-time intraoperative guidance is essential during oncological surgery for complete and safe tumour resection. Fluorescence imaging in the near-infrared spectrum has shown potential for guiding surgeons during complex interventions. Recently, there has been a shift towards the use of fluorescence contrast agents for molecular imaging. The first targeted fluorescent agents, of which most consist of approved therapeutic antibodies conjugated to a fluorescent dye, have been evaluated in several early-phase clinical trials. Moreover, advances in protein engineering and drug design have led to the development of a variety of tracers suitable for molecular fluorescence image-guided surgery. In this Review, we discuss preclinical and clinical evidence, ongoing clinical trials, and the latest developments in the field of molecular near-infrared tracers for fluorescence-guided cancer surgery.

Originele taal-2	English
Pagina's (van-tot)	E354-E367
Tijdschrift	Lancet Oncology
Volume	20
Nummer van het tijdschrift	7
DOI's	https://doi.org/10.1016/S1470-2045(19)30317-1
Status	Published - jul 2019

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10.1016/S1470-2045(19)30317-1

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1 Afgelopen
2 Actief

SRP50: SRP-Onderzoekszwaartepunt: Exploiting Peptides: Protein Binders, Modulators and Inhibitors for Imaging and Therapy [Exploit-PeptIT]
Ballet, S., Caveliers, V., Hernot, S., Versées, W., Vinken, M., Muyldermans, S., Devoogdt, N., Bridoux, J. & Martin, C.
1/03/19 → 30/09/25
Project: Fundamenteel
IOF3005: IOF GEAR: samenbrengen van multidisciplinaire en complementaire expertise voor de ontwikkeling, validatie en klinische translatie van fluorescente, op nanbodies-gebaseerde contraststoffen
Lahoutte, T., Kuijk, M., Hernot, S., Ingelberts, H., Ingelberts, H., Stroet, M., Baijot, C. M. J., Debacker, J., Iranian, P. & Lapauw, T.
1/01/19 → 31/03/25
Project: Toegepast
ANI183: Hybrid near-infrared fluorescence and nuclear imaging in ovarian cancer with uPAR-specific nanobodies for intra-operative navigation.
Hernot, S. & Mateusiak, L.
1/01/17 → 31/03/21
Project: Fundamenteel

Citeer dit

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title = "Latest developments in molecular tracers for fluorescence image-guided cancer surgery",

abstract = "Real-time intraoperative guidance is essential during oncological surgery for complete and safe tumour resection. Fluorescence imaging in the near-infrared spectrum has shown potential for guiding surgeons during complex interventions. Recently, there has been a shift towards the use of fluorescence contrast agents for molecular imaging. The first targeted fluorescent agents, of which most consist of approved therapeutic antibodies conjugated to a fluorescent dye, have been evaluated in several early-phase clinical trials. Moreover, advances in protein engineering and drug design have led to the development of a variety of tracers suitable for molecular fluorescence image-guided surgery. In this Review, we discuss preclinical and clinical evidence, ongoing clinical trials, and the latest developments in the field of molecular near-infrared tracers for fluorescence-guided cancer surgery.",

author = "Sophie Hernot and {van Manen}, Labrinus and Pieterjan Debie and Mieog, {Jan Sven David} and Vahrmeijer, {Alexander Lucas}",

year = "2019",

month = jul,

doi = "10.1016/S1470-2045(19)30317-1",

language = "English",

volume = "20",

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T1 - Latest developments in molecular tracers for fluorescence image-guided cancer surgery

AU - Hernot, Sophie

AU - van Manen, Labrinus

AU - Debie, Pieterjan

AU - Mieog, Jan Sven David

AU - Vahrmeijer, Alexander Lucas

PY - 2019/7

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N2 - Real-time intraoperative guidance is essential during oncological surgery for complete and safe tumour resection. Fluorescence imaging in the near-infrared spectrum has shown potential for guiding surgeons during complex interventions. Recently, there has been a shift towards the use of fluorescence contrast agents for molecular imaging. The first targeted fluorescent agents, of which most consist of approved therapeutic antibodies conjugated to a fluorescent dye, have been evaluated in several early-phase clinical trials. Moreover, advances in protein engineering and drug design have led to the development of a variety of tracers suitable for molecular fluorescence image-guided surgery. In this Review, we discuss preclinical and clinical evidence, ongoing clinical trials, and the latest developments in the field of molecular near-infrared tracers for fluorescence-guided cancer surgery.

AB - Real-time intraoperative guidance is essential during oncological surgery for complete and safe tumour resection. Fluorescence imaging in the near-infrared spectrum has shown potential for guiding surgeons during complex interventions. Recently, there has been a shift towards the use of fluorescence contrast agents for molecular imaging. The first targeted fluorescent agents, of which most consist of approved therapeutic antibodies conjugated to a fluorescent dye, have been evaluated in several early-phase clinical trials. Moreover, advances in protein engineering and drug design have led to the development of a variety of tracers suitable for molecular fluorescence image-guided surgery. In this Review, we discuss preclinical and clinical evidence, ongoing clinical trials, and the latest developments in the field of molecular near-infrared tracers for fluorescence-guided cancer surgery.

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SP - E354-E367

JO - Lancet Oncology

JF - Lancet Oncology

SN - 1470-2045

IS - 7

ER -

Latest developments in molecular tracers for fluorescence image-guided cancer surgery

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Projecten

SRP50: SRP-Onderzoekszwaartepunt: Exploiting Peptides: Protein Binders, Modulators and Inhibitors for Imaging and Therapy [Exploit-PeptIT]

IOF3005: IOF GEAR: samenbrengen van multidisciplinaire en complementaire expertise voor de ontwikkeling, validatie en klinische translatie van fluorescente, op nanbodies-gebaseerde contraststoffen

ANI183: Hybrid near-infrared fluorescence and nuclear imaging in ovarian cancer with uPAR-specific nanobodies for intra-operative navigation.

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