Legionella antibiotic susceptibility testing: is it time for international standardization and evidence-based guidance?

Edward Portal, Ghislaine Descours, Christophe Ginevra, Massimo Mentasti, Baharak Afshar, Meera Chand, Jessica Day, Fedoua Echahidi, Laura Franzin, Valeria Gaia, Christian Lück, Alaeddine Meghraoui, Jacob Moran-Gilad, Maria Luisa Ricci, Gerard Lina, Søren Uldum, Jonas Winchell, Robin Howe, Kathryn Bernard, Owen B SpillerVictoria J Chalker, Sophie Jarraud, Catherine Ahlen, Ibrahim Al Hashmi, Görel Allestam, Junko Amemura-Maekawa, Sabina Andersson, Jette Marie Bangsborg, Sheila Bararossa, Laetitia Beraud, Kathryn Bernard, Paola Borella, Petra Brandsema, Jacob P Bruin, Andrea Buzzigoli, Rosa Cano, Beatrice Casini, Giuseppe Celenza, Vicki Chalker, Samuel Collins, Sebastian Crespi Rotger, Maria Luisa Cristina, Sandra Cristino, Sophia David, Birgitta de Jong, Jeroen den Boer, Fedoua Echahidi, Pernille Landsbo Elverdal, Haluk Erdogan, Sjoerd Euser, Laura Franzin, Norman K Fry, Valeria Gaia, Marian Garcia-Nuñez, Christophe Ginevra, Elsa Filipa Pasmal de Ameida Concalves, Paula Gonçalves, Tiscar Graells Fernandez, Antonella Grottola, Nicole Gysin, Timothy G Harrison, Manfred Höfle, Sophie Jarraud, Charlotte Svaerke Jorgensen, Carol Joseph, Björn Slott Kanto, Darja Kese, Louise Kindingstad, Daniela Emilia Klingenberg, Mehmet Kösekul, Natalia Kozak-Muiznieks, Fumiaki Kura, Jaana Kusnetsov, Sandra Lai, Susanne Lee, John Vincent Lee, Diane Lindsay, Christian Lück, Marcel Leuscher, Wilco van der Lugt, Maria Teresa Marques, Marisa Meacci, Alaeddine Meghraoui, Massimo Mentasti, Silja Mentula, Antonija Mikrut, Josep Modol, Ginny Moore, Jacob Moran-Gilad, Matilda Morin, Selin Nar Otgun, Olav Bjarte Nataas, Neda Nezam Abadi, Katarzyna Pancer, Monica Pecorari, Maria Luisa Pedro-Botet, Carmen Pelaz, Markus Petzold, Nicholas Pissarides, Edward A R Portal, Miriam Ramliden, Brian Raphael, Kate Reddington, Maria Luisa Ricci, Emmanuel Robesyn, Sandrine Roisin, Fabio Rumpianesi, Henri Saenz, Maria Scaturro, Johanna Schalk, Graf Simone, Stine Skotte Bjerregaard, Anna Maria Spagnolo, Owen B Spiller, Anna Stjarne Aspelund, Christina Wild Svarrer, Igor Tartakovshiy, Kate Templeton, Soren Uldum, Enrico Veschetti, James Walker, France Wallet, Guenther Wewalka, Catherine Whapham, Anika Wunderlich, Ingrid Wybo

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Samenvatting

Legionella pneumophila, a Gram-negative bacillus, is the causative agent of Legionnaire's disease, a form of severe community-acquired pneumonia. Infection can have high morbidity, with a high proportion of patients requiring ICU admission, and up to 10% mortality, which is exacerbated by the lack of efficacy of typical empirical antibiotic therapy against Legionella spp. The fastidious nature of the entire Legionellaceae family historically required inclusion of activated charcoal in the solid medium to remove growth inhibitors, which inherently interferes with accurate antimicrobial susceptibility determination, an acknowledged methodological shortfall, now rectified by a new solid medium that gives results comparable to those of microbroth dilution. Here, as an international Legionella community (with authors representing various international reference laboratories, countries and clinical stakeholders for diagnosis and treatment of legionellosis), we set out recommendations for the standardization of antimicrobial susceptibility testing methods, guidelines and reference strains to facilitate an improved era of antibiotic resistance determination.

Originele taal-2English
Pagina's (van-tot)1113-1116
Aantal pagina's4
TijdschriftJournal of Antimicrobial Chemotherapy
Volume76
Nummer van het tijdschrift5
Vroegere onlinedatum20 feb 2021
DOI's
StatusPublished - 13 apr 2021

Bibliografische nota

© The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: journals.permissions@oup.com.

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