LEKTI-1 in sickness and in health

Truus Roelandt, Bert Thys, C. Heughebaert, A. De Vroede, Kristien De Paepe, Diane Roseeuw, Bartholomeus Rombaut, Jean-Pierre Hachem

Onderzoeksoutput: Article

19 Citaten (Scopus)

Samenvatting

The stratum corneum (SC) is a biosensor that mediates responses to a variety of exogenous
insults through various signaling mechanisms, including the activation of SC serine proteases
(SP) kallikrein cascade. The SPINK 5 gene encodes a SP inhibitor (SPI), the Lympho-
Epithelial-Kazal-Type-1 Inhibitor (LEKTI-1), which in turn will buffer the excess of SP
cascade initiation, key in the maintenance of permeability barrier homeostasis. We
demonstrate that LEKTI processing can occur within the SC after secretion from stratum
granulosum keratinocytes at least partially by klk7, a SC specific chymotryptic SP. Unlike the
recently described LEKTI-2, nor recombinant full-length LEKTI-1, neither recombinant
LEKTI-1 fragments exhibit anti-microbial activity. Finally we discuss the pathophysiological
implications of LEKTI-1 in skin biology as well as its contribution to the pathogenesis of
Netherton Syndrome and its potential involvement in atopic dermatitis.
Originele taal-2English
Pagina's (van-tot)247-254
Aantal pagina's8
TijdschriftInt J Cosmet Sci
Volume31
StatusPublished - 13 mei 2009

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