Low-grade endometrial stromal sarcoma treated with the aromatase inhibitor letrozole

M Leunen; M Breugelmans; Ph De Sutter; C Bourgain; J J Amy

doi:10.1016/j.ygyno.2004.07.063

Low-grade endometrial stromal sarcoma treated with the aromatase inhibitor letrozole

M Leunen, M Breugelmans, Ph De Sutter, C Bourgain, J J Amy

Onderzoeksoutput: Article › peer review

72 Citaten (Scopus)

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BACKGROUND: Low-grade endometrial stromal sarcoma is an indolent steroid responsive tumor. Successful hormonal treatment, most commonly with megestrol acetate, has been reported.

CASE: A 76-year-old woman underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy 25 years earlier allegedly for a benign condition. She presented to us with postrenal kidney failure and a huge pelvic mass compressing both ureters. After transvaginal trough-cut biopsy of the mass, the diagnosis of low-grade endometrial stromal sarcoma with a high expression of alpha-estrogen receptor was made. The patient was treated with letrozole only with a spectacular response.

CONCLUSION: To the best of our knowledge, this is the first case for which letrozole was used on long-term basis as first-line hormonal treatment for a recurrent low-grade stromal sarcoma.

Originele taal-2	English
Pagina's (van-tot)	769-771
Aantal pagina's	3
Tijdschrift	Gynecologic Oncology
Volume	95
Nummer van het tijdschrift	3
DOI's	https://doi.org/10.1016/j.ygyno.2004.07.063
Status	Published - dec. 2004

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10.1016/j.ygyno.2004.07.063

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@article{4364aaa731ac4fc985a4df77ff127bab,

title = "Low-grade endometrial stromal sarcoma treated with the aromatase inhibitor letrozole",

abstract = "BACKGROUND: Low-grade endometrial stromal sarcoma is an indolent steroid responsive tumor. Successful hormonal treatment, most commonly with megestrol acetate, has been reported.CASE: A 76-year-old woman underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy 25 years earlier allegedly for a benign condition. She presented to us with postrenal kidney failure and a huge pelvic mass compressing both ureters. After transvaginal trough-cut biopsy of the mass, the diagnosis of low-grade endometrial stromal sarcoma with a high expression of alpha-estrogen receptor was made. The patient was treated with letrozole only with a spectacular response.CONCLUSION: To the best of our knowledge, this is the first case for which letrozole was used on long-term basis as first-line hormonal treatment for a recurrent low-grade stromal sarcoma.",

keywords = "Aged, Antineoplastic Agents, Aromatase Inhibitors, Female, Humans, Neoplasm Recurrence, Local, Nitriles, Sarcoma, Endometrial Stromal, Triazoles, Case Reports, Journal Article",

author = "M Leunen and M Breugelmans and {De Sutter}, Ph and C Bourgain and Amy, {J J}",

year = "2004",

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doi = "10.1016/j.ygyno.2004.07.063",

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T1 - Low-grade endometrial stromal sarcoma treated with the aromatase inhibitor letrozole

AU - Leunen, M

AU - Breugelmans, M

AU - De Sutter, Ph

AU - Bourgain, C

AU - Amy, J J

PY - 2004/12

Y1 - 2004/12

N2 - BACKGROUND: Low-grade endometrial stromal sarcoma is an indolent steroid responsive tumor. Successful hormonal treatment, most commonly with megestrol acetate, has been reported.CASE: A 76-year-old woman underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy 25 years earlier allegedly for a benign condition. She presented to us with postrenal kidney failure and a huge pelvic mass compressing both ureters. After transvaginal trough-cut biopsy of the mass, the diagnosis of low-grade endometrial stromal sarcoma with a high expression of alpha-estrogen receptor was made. The patient was treated with letrozole only with a spectacular response.CONCLUSION: To the best of our knowledge, this is the first case for which letrozole was used on long-term basis as first-line hormonal treatment for a recurrent low-grade stromal sarcoma.

AB - BACKGROUND: Low-grade endometrial stromal sarcoma is an indolent steroid responsive tumor. Successful hormonal treatment, most commonly with megestrol acetate, has been reported.CASE: A 76-year-old woman underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy 25 years earlier allegedly for a benign condition. She presented to us with postrenal kidney failure and a huge pelvic mass compressing both ureters. After transvaginal trough-cut biopsy of the mass, the diagnosis of low-grade endometrial stromal sarcoma with a high expression of alpha-estrogen receptor was made. The patient was treated with letrozole only with a spectacular response.CONCLUSION: To the best of our knowledge, this is the first case for which letrozole was used on long-term basis as first-line hormonal treatment for a recurrent low-grade stromal sarcoma.

KW - Aged

KW - Antineoplastic Agents

KW - Aromatase Inhibitors

KW - Female

KW - Humans

KW - Neoplasm Recurrence, Local

KW - Nitriles

KW - Sarcoma, Endometrial Stromal

KW - Triazoles

KW - Case Reports

KW - Journal Article

U2 - 10.1016/j.ygyno.2004.07.063

DO - 10.1016/j.ygyno.2004.07.063

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SN - 0090-8258

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JO - Gynecologic Oncology

JF - Gynecologic Oncology

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Low-grade endometrial stromal sarcoma treated with the aromatase inhibitor letrozole

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