MEANS AND METHODS FOR TIME-RESOLVED SAMPLING

Stefania Torino (Uitvinder), Rouslan G Efremov (Uitvinder), Raf Claessens (Uitvinder)

Onderzoeksoutput: Patent

Samenvatting

The present invention relates to the field of time-resolved protein sampling, more specifically for use in structural biology, even more specifically for structural analysis of proteins by Cryogenic-electron microscopy (Cryo-EM). The invention provides for methods and devices for preparing vitrified samples for transmission electron microscopy at millisecond time-resolution using a microfluidics-based integrated device. More specifically, the sampling means and methods combine fast mixing with a tunable droplet-on-demand generation to control droplet formation, spraying and sampling velocity, resulting in a sampling method requiring very limited protein amounts.
Originele taal-2English
IPCG01N 1/28 2006.1,B01L 3/00 2006.1,G01N 1/42 2006.1
Prioriteitsdatum11/01/21
Indieningsdatum10/01/22
StatusPublished - 14 jul 2022

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