Meta-omics in Inflammatory Bowel Disease Research: Applications, Challenges, and Guidelines

Mireia Valles-Colomer, Youssef El Darzi, Sara Manuel Araujo Vieira Da Silva, Gwen Falony, Jeroen Raes, Marie Joossens

Onderzoeksoutput: Scientific reviewpeer review

32 Citaten (Scopus)

Samenvatting

Meta-omics [metagenomics, metatranscriptomics, and metaproteomics] are rapidly expanding our knowledge of the gut microbiota in health and disease. These technologies are increasingly used in inflammatory bowel disease [IBD] research. Yet, meta-omics data analysis, interpretation, and among-study comparison remain challenging. In this review we discuss the role these techniques are playing in IBD research, highlighting their strengths and limitations. We give guidelines on proper sample collection and preparation methods, and on performing the analyses and interpreting the results, reporting available user-friendly tools and pipelines.
Originele taal-2English
Pagina's (van-tot)735-746
Aantal pagina's12
TijdschriftJ Crohns Colitis
Volume10
Nummer van het tijdschrift6
DOI's
StatusPublished - 2016

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