TY - JOUR
T1 - Meta-omics in Inflammatory Bowel Disease Research: Applications, Challenges, and Guidelines
AU - Valles-Colomer, Mireia
AU - El Darzi, Youssef
AU - Araujo Vieira Da Silva, Sara Manuel
AU - Falony, Gwen
AU - Raes, Jeroen
AU - Joossens, Marie
PY - 2016
Y1 - 2016
N2 - Meta-omics [metagenomics, metatranscriptomics, and metaproteomics] are rapidly expanding our knowledge of the gut microbiota in health and disease. These technologies are increasingly used in inflammatory bowel disease [IBD] research. Yet, meta-omics data analysis, interpretation, and among-study comparison remain challenging. In this review we discuss the role these techniques are playing in IBD research, highlighting their strengths and limitations. We give guidelines on proper sample collection and preparation methods, and on performing the analyses and interpreting the results, reporting available user-friendly tools and pipelines.
AB - Meta-omics [metagenomics, metatranscriptomics, and metaproteomics] are rapidly expanding our knowledge of the gut microbiota in health and disease. These technologies are increasingly used in inflammatory bowel disease [IBD] research. Yet, meta-omics data analysis, interpretation, and among-study comparison remain challenging. In this review we discuss the role these techniques are playing in IBD research, highlighting their strengths and limitations. We give guidelines on proper sample collection and preparation methods, and on performing the analyses and interpreting the results, reporting available user-friendly tools and pipelines.
U2 - 10.1093/ecco-jcc/jjw024
DO - 10.1093/ecco-jcc/jjw024
M3 - Scientific review
VL - 10
SP - 735
EP - 746
JO - Journal of Crohn's & Colitis
JF - Journal of Crohn's & Colitis
SN - 1873-9946
IS - 6
ER -