Microarray analysis reveals abnormal chromosomal complements in over 70% of 14 normally developing human embryos

Afroditi Mertzanidou; Leeanda Wilton; Jiqiu Cheng; Claudia Spits; E. Vanneste; Yves Moreau; J.r. Vermeesch; Karen Sermon

Microarray analysis reveals abnormal chromosomal complements in over 70% of 14 normally developing human embryos

Afroditi Mertzanidou, Leeanda Wilton, Jiqiu Cheng, Claudia Spits, E. Vanneste, Yves Moreau, J.r. Vermeesch, Karen Sermon

Onderzoeksoutput: Article › peer review

166 Citaten (Scopus)

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STUDY QUESTION: What are the aneuploidy rates and incidence of mosaicism in good-quality human preimplantation embryos. SUMMARY ANSWER: High-level mosaicism and structural aberrations are not restricted to arrested or poorly developing embryos but are also common in good-quality IVF embryos. WHAT IS KNOWN ALREADY: Humans, compared with other mammals, have a poor fertility rate, and even IVF treatments have a relatively low success rate. It is known that human gametes and early preimplantation embryos carry chromosomal abnormalities that are thought to lower their developmental potential. STUDY DESIGN, SIZE AND DURATION: The embryos studied came from nine young (age

Originele taal-2	English
Pagina's (van-tot)	256-264
Aantal pagina's	9
Tijdschrift	Human Reproduction
Volume	28
Status	Published - 28 jan 2013

IWT330: Molecular Karyotyping
Mertzanidou, A., Sermon, K. & Liebaers, I.
1/10/07 → 30/09/11
Project: Fundamenteel

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abstract = "STUDY QUESTION: What are the aneuploidy rates and incidence of mosaicism in good-quality human preimplantation embryos. SUMMARY ANSWER: High-level mosaicism and structural aberrations are not restricted to arrested or poorly developing embryos but are also common in good-quality IVF embryos. WHAT IS KNOWN ALREADY: Humans, compared with other mammals, have a poor fertility rate, and even IVF treatments have a relatively low success rate. It is known that human gametes and early preimplantation embryos carry chromosomal abnormalities that are thought to lower their developmental potential. STUDY DESIGN, SIZE AND DURATION: The embryos studied came from nine young (age",

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author = "Afroditi Mertzanidou and Leeanda Wilton and Jiqiu Cheng and Claudia Spits and E. Vanneste and Yves Moreau and J.r. Vermeesch and Karen Sermon",

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T1 - Microarray analysis reveals abnormal chromosomal complements in over 70% of 14 normally developing human embryos

AU - Mertzanidou, Afroditi

AU - Wilton, Leeanda

AU - Cheng, Jiqiu

AU - Spits, Claudia

AU - Vanneste, E.

AU - Moreau, Yves

AU - Vermeesch, J.r.

AU - Sermon, Karen

PY - 2013/1/28

Y1 - 2013/1/28

N2 - STUDY QUESTION: What are the aneuploidy rates and incidence of mosaicism in good-quality human preimplantation embryos. SUMMARY ANSWER: High-level mosaicism and structural aberrations are not restricted to arrested or poorly developing embryos but are also common in good-quality IVF embryos. WHAT IS KNOWN ALREADY: Humans, compared with other mammals, have a poor fertility rate, and even IVF treatments have a relatively low success rate. It is known that human gametes and early preimplantation embryos carry chromosomal abnormalities that are thought to lower their developmental potential. STUDY DESIGN, SIZE AND DURATION: The embryos studied came from nine young (age

AB - STUDY QUESTION: What are the aneuploidy rates and incidence of mosaicism in good-quality human preimplantation embryos. SUMMARY ANSWER: High-level mosaicism and structural aberrations are not restricted to arrested or poorly developing embryos but are also common in good-quality IVF embryos. WHAT IS KNOWN ALREADY: Humans, compared with other mammals, have a poor fertility rate, and even IVF treatments have a relatively low success rate. It is known that human gametes and early preimplantation embryos carry chromosomal abnormalities that are thought to lower their developmental potential. STUDY DESIGN, SIZE AND DURATION: The embryos studied came from nine young (age

KW - human preimplantation embryo

KW - chromosomal abnormality

M3 - Article

VL - 28

SP - 256

EP - 264

JO - Human Reproduction

JF - Human Reproduction

SN - 0268-1161

ER -

Microarray analysis reveals abnormal chromosomal complements in over 70% of 14 normally developing human embryos

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IWT330: Molecular Karyotyping

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