Monocytic myeloid-derived suppressor cells home to tumor-draining lymph nodes via CCR2 and locally modulate the immune response

Qods Lahmar, Elio Schouppe, Yannick Morias, Eva Van Overmeire, Patrick De Baetselier, Kiavash Movahedi, Damya Laoui, Adelaida Sarukhan, Jo A Van Ginderachter

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3 Citaten (Scopus)

Samenvatting

Efficient priming of anti-tumor T cells requires the uptake and presentation of tumor antigens by immunogenic dendritic cells (DCs) and occurs mainly in lymph nodes draining the tumor (tdLNs). However, tumors expand and activate myeloid-derived suppressor cells (MDSCs) that inhibit CTL functions by several mechanisms. While the immune-suppressive nature of the tumor microenvironment is largely documented, it is not known whether similar immune-suppressive mechanisms operate in the tdLNs. In this study, we analyzed MDSC characteristics within tdLNs. We show that, in a metastasis-free context, MO-MDSCs are the dominant MDSC population within tdLNs, that they are highly suppressive and that tumor proximity enhances their recruitment to tdLN via a CCR2/CCL2-dependent pathway. Altogether our results uncover a mechanism by which tumors evade the immune system that involves MDSC-mediated recruitment to the tdLN and the inhibition of T-cell activation even before reaching the highly immunosuppressive tumor microenvironment.

Originele taal-2English
Artikelnummer104296
Aantal pagina's8
TijdschriftCellular Immunology
Volume362
Vroegere onlinedatum30 jan 2021
DOI's
StatusPublished - apr 2021

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Copyright © 2021 Elsevier Inc. All rights reserved.

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