TY - JOUR
T1 - Mouse in vitro fertilization using sperm treated with pentoxifylline and 2-deoxyadenosine.
AU - Tournaye, Herman
AU - Van Der Linden, Marleen
AU - Van Den Abbeel, Etienne
AU - Devroey, Paul
AU - Van Steirteghem, Andre
N1 - Fertil Steril 62, 644-647, 1994.
PY - 1994
Y1 - 1994
N2 - If sperm were treated by both pentoxifylline and 2-deoxyadenosine before insemination of postovulatory mouse oocytes, two-cell embryo formation was found to be reduced even if both agents were eluted from the sperm before insemination. If these agents were not washed out before insemination, an adverse effect on early embryonic development was noted, that is, the numbers of two-cell embryos reaching the blastocyst stage and the numbers of blastocysts able to form the egg cylinder were found to be reduced. However, egg-cylinder formation was also found to be reduced when both compounds were washed out before insemination.
AB - If sperm were treated by both pentoxifylline and 2-deoxyadenosine before insemination of postovulatory mouse oocytes, two-cell embryo formation was found to be reduced even if both agents were eluted from the sperm before insemination. If these agents were not washed out before insemination, an adverse effect on early embryonic development was noted, that is, the numbers of two-cell embryos reaching the blastocyst stage and the numbers of blastocysts able to form the egg cylinder were found to be reduced. However, egg-cylinder formation was also found to be reduced when both compounds were washed out before insemination.
M3 - Article
VL - 62
SP - 644
EP - 647
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - September
ER -