Samenvatting
Objective.We aimed to analyze whether complexity of brain electrical activity (EEG) measured by multiscale entropy (MSE) increases with brain maturation during the first two years of life. We also aimed to investigate whether this complexity shows regional differences across the brain, and whether changes in complexity are influenced by extrauterine life experience duration.Approach.We measured MSE of EEG signals recorded longitudinally using a high-density setup (64 or 128 electrodes) in 84 typically developing infants born preterm (<32 weeks' gestation) from term age to two years. We analyzed the complexity index and maximum value of MSE over increasing age, across brain regions, and in function of extrauterine life duration, and used correlation matrices as a metric of functional connectivity of the cerebral cortex.Main results.We found an increase of strong inter-channel correlation of MSE (R > 0.8) with increasing age. Regional analysis showed significantly increased MSE between 3 and 24 months of corrected age in the posterior and middle regions with respect to the anterior region. We found a weak relationship (adjusted R2= 0.135) between MSE and extrauterine life duration.Significance.These findings suggest that brain functional connectivity increases with maturation during the first two years of life. EEG complexity shows regional differences with earlier maturation of the visual cortex and brain regions involved in joint attention than of regions involved in cognitive analysis, abstract thought, and social behavior regulation. Finally, our MSE analysis suggested only a weak influence of early extrauterine life experiences (prior to term age) on EEG complexity.
| Originele taal-2 | English |
|---|---|
| Artikelnummer | 125001 |
| Tijdschrift | Physiological Measurement |
| Volume | 43 |
| Nummer van het tijdschrift | 12 |
| DOI's | |
| Status | Published - 30 dec 2022 |
Bibliografische nota
Funding Information:We are grateful to the children who participated in the study and their family. We thank Karin Duponcelle and Irit Daniel for technical assistance. We are also indebted to Guy Cheron, Ana Maria Cebolla, and Mathieu Petieau with useful discussions. This work was supported by the Fondation Roger de Spoelberch, the Fondation JED and the Fonds Iris Recherche. The Fondation Roger de Spoelberch supports the Primebrain project in which infants are longitudinally assessed; the assessments include high-density EEG and ERP. The support is financial and the authors retain full scientific independence. The Fondation JED and the Fonds Iris Recherche each contributed towards the cost of the recording and analysis equipment for high-density EEG. BD was the inaugural recipient of the Elsass Foundation Research Prize, which was used in part to support this study. The support is financial and the authors retain full scientific independence. The authors have no interests that might be perceived as posing a conflict or bias.
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© 2022 Institute of Physics and Engineering in Medicine.
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