Samenvatting
Mycophenolate Mofetil (MMF) is a new immunosuppressive agent that selectively inhibits the proliferation of T and B lymphocytes. The use of MMF in renal transplantation significantly reduced the incidence of acute rejection episodes in the first year after transplantation. The main toxicities of MMF are the occurrence of diarrhea and leucopenia. This potent immunosuppressive agent is devoid of the nephrotoxicity of cyclosporin and of the multiple adverse effects of corticosteroids. Clinical trials are currently in progress to assess whether the use of MMF will allow the discontinuation of cyclosporine or corticosteroid therapy without leading to an increased risk of rejection. If results were positive, MMF would represent a significant advance in the field of renal transplantation.
Vertaalde titel van de bijdrage | Mycophenolate mofetil |
---|---|
Originele taal-2 | French |
Pagina's (van-tot) | 139-143 |
Aantal pagina's | 5 |
Tijdschrift | Revue Médicale de Bruxelles |
Volume | 19 |
Nummer van het tijdschrift | 3 |
Status | Published - jun 1998 |
Keywords
- Acute Disease
- Adrenal Cortex Hormones
- B-Lymphocytes
- Cell Division
- Clinical Trials as Topic
- Cyclosporine
- Diarrhea
- Graft Rejection
- Humans
- Immunosuppressive Agents
- Incidence
- Kidney
- Kidney Transplantation
- Leukopenia
- Mycophenolic Acid
- Risk Factors
- T-Lymphocytes