New tetracyclic tetrahydro-beta-carbolines as tryptophan-derived peptidomimetics

Karolina Pulka, Debby Feytens, A Misicka, Dirk Tourwe

Onderzoeksoutput: Articlepeer review

9 Citaten (Scopus)

Samenvatting

Abstract: The Pictet-Spengler reaction is known as a useful tool for the synthesis of constrained analogs of tryptophan. Herein, we present the further cyclization of 1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid methyl esters with 1-(1'-aminoalkyl) side chain. These transformations lead to heterocyclic structures which can find useful applications in medicinal chemistry as peptide mimetics
Originele taal-2English
Pagina's (van-tot)97-108
Aantal pagina's12
TijdschriftMolecular Diversity
Volume14
Nummer van het tijdschrift1
StatusPublished - 1 feb 2010

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