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Cellular communication mediated by gap junction channels and hemichannels, both composed of connexin proteins, constitutes two acknowledged regulatory platforms in the accomplishment of tissue homeostasis. In recent years, an abundance of reports has been published indicating functions for connexin proteins in the control of the cellular life cycle that occur independently of their channel activities. This has yet been most exemplified in the context of cell growth and cell death, and is therefore as such addressed in the current paper. Specific attention is hereby paid to the molecular mechanisms that underpin the cellular non-channel roles of connexin proteins, namely the alteration of the expression of homeostasis determinants and the physical interaction with cell growth and cell death regulators.
|Tijdschrift||Biochimica et Biophysica Acta - Biomembranes|
|Status||Published - 1 jun 2012|
VingerafdrukDuik in de onderzoeksthema's van 'Non-channel functions of connexins in cell growth and cell death'. Samen vormen ze een unieke vingerafdruk.
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