On the Existence of Synergies and the Separability of Closed Reaction Networks

Tomas Veloz, Alejandro Bassi, Pedro Maldonado, Pablo Razeto

    Onderzoeksoutput: Conference paper

    4 Citaten (Scopus)

    Samenvatting

    It is well known that closure is a necessary topological property for a reaction network to be dynamically stable. In this work we combine notions of chemical organization theory with structural properties of reaction networks to distill a minimal set of closed reaction networks that encodes the non-trivial stable dynamical regimes of the network. In particular, these non-trivial closed sets are synergetic, in the sense that their dynamics cannot always be computed from the dynamics of its closed constituents. We introduce a notion of separability for reaction networks and prove that it is strictly related to the notion of synergy. In particular, we provide a characterization of the non-trivial closed reaction networks by means of their degree of internal synergy. The less trivial the dynamics of the reaction network, the less can be separated into constituents, and equivalently the more synergies the reaction network has. We also discuss the computational and analytical benefits of this new representation of the dynamical structure of a reaction network.

    Originele taal-2English
    TitelMolecular Logic and Computational Synthetic Biology - 1st International Symposium, MLCSB 2018, Revised Selected Papers
    RedacteurenManuel A. Martins, Madalena Chaves
    UitgeverijSpringer Verlag
    Pagina's105-120
    Aantal pagina's16
    ISBN van geprinte versie9783030194314
    DOI's
    StatusPublished - 1 jan 2019
    Evenement1st International Symposium on Molecular Logic and Computational Synthetic Biology, MLCSB 2018 - Santiago, Chile
    Duur: 17 dec 201818 dec 2018

    Publicatie series

    NaamLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
    Volume11415 LNCS
    ISSN van geprinte versie0302-9743
    ISSN van elektronische versie1611-3349

    Conference

    Conference1st International Symposium on Molecular Logic and Computational Synthetic Biology, MLCSB 2018
    Land/RegioChile
    StadSantiago
    Periode17/12/1818/12/18

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