Oral R115866 in the treatment of moderate to severe facial acne vulgaris: an exploratory study

C. Verfaille, M. Coel, Boersma H., J. Moertens, M. Borgers, Diane Roseeuw

Onderzoeksoutput: Article

30 Citaten (Scopus)

Samenvatting

BACKGROUND: R115866 (Rambazole; Barrier Therapeutics NV, Geel, Belgium), a new-generation retinoic acid metabolism-blocking agent, is a nonretinoid compound enhancing intracellularly the endogenous levels of all-trans-retinoic acid by blocking its catabolism. By virtue of this property, and the proven positive effects of retinoids in the treatment of acne, R115866 could potentially be a useful drug for acne. OBJECTIVES: To explore the efficacy, safety and tolerability of systemic R115866 in male patients with moderate to severe facial acne vulgaris (at least 15 papules and/or pustules and at least two nodulocystic lesions). METHODS: In this exploratory trial, 17 patients were treated with oral R115866 1 mg once daily for 12 weeks, followed by a 4-week treatment-free period. RESULTS: At the end of treatment (week 12, n = 16) a mean reduction in inflammatory lesion count of 77.4% (P <0.001), in noninflammatory lesion count of 58.3% (P <0.001) and in total lesion count of 76.0% (P <0.001) was observed as compared with baseline. All lesion counts were significantly reduced from week 4 onwards. Mild side-effects were reported occasionally. CONCLUSIONS: The current data indicate that treatment with oral R115866 1 mg once daily for 12 weeks in patients with moderate to severe facial acne vulgaris is efficacious and well tolerated and merits further investigation.
Originele taal-2English
Pagina's (van-tot)122-126
Aantal pagina's5
TijdschriftBr J Dermatol
Nummer van het tijdschrift157
StatusPublished - 2007

Vingerafdruk

Duik in de onderzoeksthema's van 'Oral R115866 in the treatment of moderate to severe facial acne vulgaris: an exploratory study'. Samen vormen ze een unieke vingerafdruk.

Citeer dit