Projecten per jaar
Samenvatting
Pannexins form channels at the plasma membrane surface that establish a pathway for communication between the cytosol of individual cells and their extracellular environment. By doing so, pannexin signaling dictates several physiological functions, but equally underlies a number of pathological processes. Indeed, pannexin channels drive inflammation by assisting in the activation of inflammasomes, the release of pro-inflammatory cytokines, and the activation and migration of leukocytes. Furthermore, these cellular pores facilitate cell death, including apoptosis, pyroptosis and autophagy. The present paper reviews the roles of pannexin channels in inflammation and cell death. In a first part, a state-of-the-art overview of pannexin channel structure, regulation and function is provided. In a second part, the mechanisms behind their involvement in inflammation and cell death are discussed.
Originele taal-2 | English |
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Pagina's (van-tot) | 51-61 |
Aantal pagina's | 11 |
Tijdschrift | Biochemica et Biophysica Acta - Molecular Cell Research |
Volume | 1864 |
Nummer van het tijdschrift | 1 |
DOI's | |
Status | Published - 2017 |
Bibliografische nota
Copyright © 2016 Elsevier B.V. All rights reserved.Vingerafdruk
Duik in de onderzoeksthema's van 'Pannexin1 as mediator of inflammation and cell death'. Samen vormen ze een unieke vingerafdruk.-
OZR2651: Internationale alliantie-onderzoeksgroep: hepatische connexines en pannexines
Vinken, M., Rogiers, V., Cogliati, B. & Dagli, M. L.
1/08/14 → 1/07/26
Project: Fundamenteel
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OZR2813: Bilaterale samenwerking ikv gemeenschappelijke doctoraatsproject: Bench Fee voor Joint PhD VUB-Universidade de Sao Paulo, Michael Maes
10/06/15 → 31/07/17
Project: Fundamenteel
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Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity
Maes, M., McGill, M. R., da Silva, T. C., Abels, C., Lebofsky, M., Weemhoff, J. L., Tiburcio, T., Veloso Alves Pereira, I., Willebrords, J., Crespo Yanguas, S., Farhood, A., Beschin, A., Van Ginderachter, J. A., Penuela, S., Jaeschke, H., Cogliati, B. & Vinken, M., 1 mei 2017, In: Archives of Toxicology. 91, 5, blz. 2245-2261 17 blz.Onderzoeksoutput: Article › peer review
17 Citaten (Scopus) -
Pannexin1 channel inhibition attenuates neutrophil recruitment upon acetaminophen-induced hepatotoxicity
Maes, M., Abels, C., Willebrords, J., Crespo Yanguas, S., Beschin, A., Jaeschke, H., Van Ginderachter, J., Cogliati, B. & Vinken, M., 1 nov 2016, In: Hepatology. 64, s1, 1 blz., 697.Onderzoeksoutput: Meeting abstract (Journal)
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The role of connexins, pannexins and their channels in liver fibrosis
Sara Crespo Yanguas (Speaker)
28 nov 2018Activiteit: Talk or presentation at a workshop/seminar
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The Liver Meeting 2016 of the American Association for the Study on Liver Diseases
Michaël Maes (Invited speaker)
11 nov 2016 → 15 nov 2016Activiteit: Talk or presentation at a conference
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In vitro characterization of connexin and pannexin (hemi)channel inhibitors:target selectivity and anti-fibrotic efficacy
Sara Crespo Yanguas (Speaker)
14 apr 2015Activiteit: Talk or presentation at a workshop/seminar