Pannexin1 as mediator of inflammation and cell death

Sara Crespo Yanguas, Joost Willebrords, Scott R. Johnstone, Michaël Maes, Elke Decrock, Marijke De Bock, Luc Leybaert, Bruno Cogliati, Mathieu Vinken

Onderzoeksoutput: Articlepeer review

85 Citaten (Scopus)

Samenvatting

Pannexins form channels at the plasma membrane surface that establish a pathway for communication between the cytosol of individual cells and their extracellular environment. By doing so, pannexin signaling dictates several physiological functions, but equally underlies a number of pathological processes. Indeed, pannexin channels drive inflammation by assisting in the activation of inflammasomes, the release of pro-inflammatory cytokines, and the activation and migration of leukocytes. Furthermore, these cellular pores facilitate cell death, including apoptosis, pyroptosis and autophagy. The present paper reviews the roles of pannexin channels in inflammation and cell death. In a first part, a state-of-the-art overview of pannexin channel structure, regulation and function is provided. In a second part, the mechanisms behind their involvement in inflammation and cell death are discussed.
Originele taal-2English
Pagina's (van-tot)51-61
Aantal pagina's11
TijdschriftBiochemica et Biophysica Acta - Molecular Cell Research
Volume1864
Nummer van het tijdschrift1
DOI's
StatusPublished - 2017

Bibliografische nota

Copyright © 2016 Elsevier B.V. All rights reserved.

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