Pannexin1 channels in the liver: an open enemy.

Raf Van Campenhout; Anne Caufriez; Andres Tabernilla Garcia; Amy Maerten; Sybren De Boever; Julen Sanz-Serrano; Prashant Kadam; Mathieu Vinken

doi:10.3389/fcell.2023.1220405

Pannexin1 channels in the liver: an open enemy.

Raf Van Campenhout, Anne Caufriez, Andres Tabernilla Garcia, Amy Maerten, Sybren De Boever, Julen Sanz-Serrano, Prashant Kadam, Mathieu Vinken

Onderzoeksoutput: Article › peer review

1 Citaat (Scopus)

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Samenvatting

Pannexin1 proteins form communication channels at the cell plasma membrane surface, which allow the transfer of small molecules and ions between the intracellular compartment and extracellular environment. In this way, pannexin1 channels play an important role in various cellular processes and diseases. Indeed, a plethora of human pathologies is associated with the activation of pannexin1 channels. The present paper reviews and summarizes the structure, life cycle, regulation and (patho)physiological roles of pannexin1 channels, with a particular focus on the relevance of pannexin1 channels in liver diseases.

Originele taal-2	English
Artikelnummer	1220405
Aantal pagina's	14
Tijdschrift	Frontiers in cell and developmental biology
Volume	11
DOI's	https://doi.org/10.3389/fcell.2023.1220405
Status	Published - 25 jul 2023

Bibliografische nota

Funding Information:
This work was financially supported by the European Future and Emerging Technologies program (grant 858014 “PANACHE”), the Fund for Scientific Research Research-Flanders, the University Hospital of the Vrije Universiteit Brussel-Belgium (“Willy Gepts Fonds” UZ-VUB) and the Methusalem program of the Flemish government-Belgium.

Publisher Copyright:
Copyright © 2023 Van Campenhout, Caufriez, Tabernilla, Maerten, De Boever, Sanz-Serrano, Kadam and Vinken.

Copyright:
Copyright 2023 Elsevier B.V., All rights reserved.

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10.3389/fcell.2023.1220405Licentie: CC BY

paperFinal published version, 1,92 MBLicentie: CC BY

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1 Actief
2 Afgelopen

FWOAL1070: De rol van pannexine1 kanalen in niet-alcoholische steatohepatitis: therapeutische en diagnostische relevantie.
Vinken, M.
1/01/23 → 31/12/26
Project: Fundamenteel
FWOAL879: 'Nanobody'-gebaseerde inhibitoren van connexine hemikanalen en pannexine kanalen als nieuwe therapeutica voor de behandeling van inflammatoire aandoeningen in de lever en het cardiovasculair systeem.
Vinken, M., Muyldermans, S. & Kwak, B. R.
1/01/18 → 31/12/21
Project: Fundamenteel
FWOAL887: Zijn connexine hemikanalen en pannexine kanalen therapeutische doelwitten en diagnostische biomerkers in cholestase?
Vinken, M. & Annaert, P.
1/01/18 → 31/12/21
Project: Fundamenteel

Citeer dit

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title = "Pannexin1 channels in the liver: an open enemy.",

abstract = "Pannexin1 proteins form communication channels at the cell plasma membrane surface, which allow the transfer of small molecules and ions between the intracellular compartment and extracellular environment. In this way, pannexin1 channels play an important role in various cellular processes and diseases. Indeed, a plethora of human pathologies is associated with the activation of pannexin1 channels. The present paper reviews and summarizes the structure, life cycle, regulation and (patho)physiological roles of pannexin1 channels, with a particular focus on the relevance of pannexin1 channels in liver diseases.",

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note = "Funding Information: This work was financially supported by the European Future and Emerging Technologies program (grant 858014 “PANACHE”), the Fund for Scientific Research Research-Flanders, the University Hospital of the Vrije Universiteit Brussel-Belgium (“Willy Gepts Fonds” UZ-VUB) and the Methusalem program of the Flemish government-Belgium. Publisher Copyright: Copyright {\textcopyright} 2023 Van Campenhout, Caufriez, Tabernilla, Maerten, De Boever, Sanz-Serrano, Kadam and Vinken. Copyright: Copyright 2023 Elsevier B.V., All rights reserved.",

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AU - Van Campenhout, Raf

AU - Caufriez, Anne

AU - Tabernilla Garcia, Andres

AU - Maerten, Amy

AU - De Boever, Sybren

AU - Sanz-Serrano, Julen

AU - Kadam, Prashant

AU - Vinken, Mathieu

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PY - 2023/7/25

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AB - Pannexin1 proteins form communication channels at the cell plasma membrane surface, which allow the transfer of small molecules and ions between the intracellular compartment and extracellular environment. In this way, pannexin1 channels play an important role in various cellular processes and diseases. Indeed, a plethora of human pathologies is associated with the activation of pannexin1 channels. The present paper reviews and summarizes the structure, life cycle, regulation and (patho)physiological roles of pannexin1 channels, with a particular focus on the relevance of pannexin1 channels in liver diseases.

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ER -

Pannexin1 channels in the liver: an open enemy.

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Bibliografische nota

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Andere bestanden en links

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Projecten

FWOAL1070: De rol van pannexine1 kanalen in niet-alcoholische steatohepatitis: therapeutische en diagnostische relevantie.

FWOAL879: 'Nanobody'-gebaseerde inhibitoren van connexine hemikanalen en pannexine kanalen als nieuwe therapeutica voor de behandeling van inflammatoire aandoeningen in de lever en het cardiovasculair systeem.

FWOAL887: Zijn connexine hemikanalen en pannexine kanalen therapeutische doelwitten en diagnostische biomerkers in cholestase?

Citeer dit