Samenvatting
OBJECTIVE: To assess the efficiency of the addition of pentoxifylline to spermatozoa for in vitro fertilization (IVF) in cases with previous fertilization failure. DESIGN: After retrieval, oocytes were divided at random and inseminated with spermatozoa prepared with or without pentoxifylline. SETTING: In vitro fertilization program of the Centre for Reproductive Medicine of the Dutch-speaking Brussels Free University, Belgium, a tertiary referral institution. PATIENTS: Couples in this study were undergoing a second or third IVF attempt for the treatment of male factor infertility. INTERVENTIONS: Sperm samples were divided into two equal parts. The first part was prepared with 3.6 mM pentoxifylline (treatment group) and the other part without pentoxifylline (control group). After swim-up, oocytes were randomly inseminated with spermatozoa from either treatment. MAIN OUTCOME MEASURES: Fertilization and cleavage rates after IVF. RESULTS: Overall a fertilization rate of 8.8% was achieved with no significant differences between treatment and control groups. Cleavage rate was 81.5% and was not different between groups. CONCLUSIONS: This study demonstrates no therapeutic advantage of using pentoxifylline in IVF for male factor infertility in cases with previous fertilization failure.
Originele taal-2 | English |
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Pagina's (van-tot) | 210-215 |
Aantal pagina's | 6 |
Tijdschrift | Fertil Steril |
Volume | 59 |
Nummer van het tijdschrift | January |
Status | Published - 1993 |