Peroxiredoxins wear many hats: Factors that fashion their peroxide sensing personalities

Onderzoeksoutput: Scientific reviewpeer review

28 Citaten (Scopus)
108 Downloads (Pure)


Peroxiredoxins (Prdxs) sense and assess peroxide levels, and signal through protein interactions. Understanding the role of the multiple structural and post-translational modification (PTM) layers that tunes the peroxiredoxin specificities is still a challenge. In this review, we give a tabulated overview on what is known about human and bacterial peroxiredoxins with a focus on structure, PTMs, and protein-protein interactions. Armed with numerous cellular and atomic level experimental techniques, we look at the future and ask ourselves what is still needed to give us a clearer view on the cellular operating power of Prdxs in both stress and non-stress conditions.

Originele taal-2English
Aantal pagina's17
TijdschriftRedox Biology
StatusPublished - jun 2021

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