Peroxiredoxins wear many hats: Factors that fashion their peroxide sensing personalities

Jesalyn Bolduc; Katarina Koruza; Ting Luo; Julia Malo Pueyo; Trung Nghia Vo; Daria Ezeriņa; Joris Messens

doi:10.1016/j.redox.2021.101959

Peroxiredoxins wear many hats: Factors that fashion their peroxide sensing personalities

Jesalyn Bolduc, Katarina Koruza, Ting Luo, Julia Malo Pueyo, Trung Nghia Vo, Daria Ezeriņa, Joris Messens

Onderzoeksoutput: Scientific review › peer review

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Peroxiredoxins (Prdxs) sense and assess peroxide levels, and signal through protein interactions. Understanding the role of the multiple structural and post-translational modification (PTM) layers that tunes the peroxiredoxin specificities is still a challenge. In this review, we give a tabulated overview on what is known about human and bacterial peroxiredoxins with a focus on structure, PTMs, and protein-protein interactions. Armed with numerous cellular and atomic level experimental techniques, we look at the future and ask ourselves what is still needed to give us a clearer view on the cellular operating power of Prdxs in both stress and non-stress conditions.

Originele taal-2	English
Artikelnummer	101959
Aantal pagina's	17
Tijdschrift	Redox Biology
Volume	42
DOI's	https://doi.org/10.1016/j.redox.2021.101959
Status	Published - jun. 2021

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title = "Peroxiredoxins wear many hats: Factors that fashion their peroxide sensing personalities",

abstract = "Peroxiredoxins (Prdxs) sense and assess peroxide levels, and signal through protein interactions. Understanding the role of the multiple structural and post-translational modification (PTM) layers that tunes the peroxiredoxin specificities is still a challenge. In this review, we give a tabulated overview on what is known about human and bacterial peroxiredoxins with a focus on structure, PTMs, and protein-protein interactions. Armed with numerous cellular and atomic level experimental techniques, we look at the future and ask ourselves what is still needed to give us a clearer view on the cellular operating power of Prdxs in both stress and non-stress conditions.",

author = "Jesalyn Bolduc and Katarina Koruza and Ting Luo and {Malo Pueyo}, Julia and Vo, {Trung Nghia} and Daria Ezeriņa and Joris Messens",

note = "Funding Information: This work was funded with a VIB grant (to J.M.), and the Research Foundation-Flanders –Fonds de la Recherche Scientifique Excellence of Science project no. 30829584 (to J.M). Ting L. was supported with a Chinese Scholarship Council grant (File No. 201707650018 ). Funding Information: This work was funded with a VIB grant (to J.M.), and the Research Foundation-Flanders?Fonds de la Recherche Scientifique Excellence of Science project no. 30829584 (to J.M). Ting L. was supported with a Chinese Scholarship Council grant (File No. 201707650018). Publisher Copyright: {\textcopyright} 2021 The Author(s)",

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month = jun,

doi = "10.1016/j.redox.2021.101959",

language = "English",

volume = "42",

journal = "Redox Biology",

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T1 - Peroxiredoxins wear many hats: Factors that fashion their peroxide sensing personalities

AU - Bolduc, Jesalyn

AU - Koruza, Katarina

AU - Luo, Ting

AU - Malo Pueyo, Julia

AU - Vo, Trung Nghia

AU - Ezeriņa, Daria

AU - Messens, Joris

N1 - Funding Information: This work was funded with a VIB grant (to J.M.), and the Research Foundation-Flanders –Fonds de la Recherche Scientifique Excellence of Science project no. 30829584 (to J.M). Ting L. was supported with a Chinese Scholarship Council grant (File No. 201707650018 ). Funding Information: This work was funded with a VIB grant (to J.M.), and the Research Foundation-Flanders?Fonds de la Recherche Scientifique Excellence of Science project no. 30829584 (to J.M). Ting L. was supported with a Chinese Scholarship Council grant (File No. 201707650018). Publisher Copyright: © 2021 The Author(s)

PY - 2021/6

Y1 - 2021/6

N2 - Peroxiredoxins (Prdxs) sense and assess peroxide levels, and signal through protein interactions. Understanding the role of the multiple structural and post-translational modification (PTM) layers that tunes the peroxiredoxin specificities is still a challenge. In this review, we give a tabulated overview on what is known about human and bacterial peroxiredoxins with a focus on structure, PTMs, and protein-protein interactions. Armed with numerous cellular and atomic level experimental techniques, we look at the future and ask ourselves what is still needed to give us a clearer view on the cellular operating power of Prdxs in both stress and non-stress conditions.

AB - Peroxiredoxins (Prdxs) sense and assess peroxide levels, and signal through protein interactions. Understanding the role of the multiple structural and post-translational modification (PTM) layers that tunes the peroxiredoxin specificities is still a challenge. In this review, we give a tabulated overview on what is known about human and bacterial peroxiredoxins with a focus on structure, PTMs, and protein-protein interactions. Armed with numerous cellular and atomic level experimental techniques, we look at the future and ask ourselves what is still needed to give us a clearer view on the cellular operating power of Prdxs in both stress and non-stress conditions.

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M3 - Scientific review

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SN - 2213-2317

VL - 42

JO - Redox Biology

JF - Redox Biology

M1 - 101959

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Peroxiredoxins wear many hats: Factors that fashion their peroxide sensing personalities

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