POSTER: The role of invading immune cells expressing or lacking system xc- in an experimental model for multiple sclerosis

Ellen Merckx, Magdalena Paterka, Joeri Van Liefferinge, Eduard Mihai Bentea, Thomas Demuyser, Giulia Albertini, Ilse Julia Smolders, Jacques De Keyser, Hideyo Sato, Axel Methner, Ann Massie

Onderzoeksoutput: Meeting abstract (Book)

Samenvatting

Multiplesclerosis (MS) is one of the most frequent disorders of the central nervous system. Excitotoxicity as well as oxidative stress are part of the pathogenesis, in accordance to other neurological diseases. The cystine/glutamate antiporter or system xc-, with xCT as specific subunit, imports cystine in exchange for glutamate and can as such affect intracellular antioxidant as well as extracellular glutamate levels. Oxidative stress induces the expression of xCT and could consequently aggravate excitotoxic damage. Increased activity of system xc- results in protection against oxidative stress, but at the same time gives rise to toxic extracellular glutamate concentrations. With this project we aim at unveiling the role of system xc-in the pathogenesis of MS.
Originele taal-2English
TitelCenter for Neurosciences PhD Day, Brussels, Belgium, March 13, 2014
StatusPublished - 2014
EvenementPhD day Center for Neurosciences - Faculty of Medicine, Vrije Universiteit Brussel., Brussels, Belgium
Duur: 13 mrt 201413 mrt 2014

Seminar

SeminarPhD day Center for Neurosciences
Land/RegioBelgium
StadBrussels
Periode13/03/1413/03/14

Vingerafdruk

Duik in de onderzoeksthema's van 'POSTER: The role of invading immune cells expressing or lacking system xc- in an experimental model for multiple sclerosis'. Samen vormen ze een unieke vingerafdruk.

Citeer dit