Samenvatting
Multiplesclerosis (MS) is one of the most frequent disorders of the central nervous system. Excitotoxicity as well as oxidative stress are part of the pathogenesis, in accordance to other neurological diseases. The cystine/glutamate antiporter or system xc-, with xCT as specific subunit, imports cystine in exchange for glutamate and can as such affect intracellular antioxidant as well as extracellular glutamate levels. Oxidative stress induces the expression of xCT and could consequently aggravate excitotoxic damage. Increased activity of system xc- results in protection against oxidative stress, but at the same time gives rise to toxic extracellular glutamate concentrations. With this project we aim at unveiling the role of system xc-in the pathogenesis of MS.
Originele taal-2 | English |
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Titel | Center for Neurosciences PhD Day, Brussels, Belgium, March 13, 2014 |
Status | Published - 2014 |
Evenement | PhD day Center for Neurosciences - Faculty of Medicine, Vrije Universiteit Brussel., Brussels, Belgium Duur: 13 mrt 2014 → 13 mrt 2014 |
Seminar
Seminar | PhD day Center for Neurosciences |
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Land/Regio | Belgium |
Stad | Brussels |
Periode | 13/03/14 → 13/03/14 |