Poster: Transcranial direct current stimulation for the treatment of motor sequence learning in Parkinson’s patients with mild cognitive impairment

Onderzoeksoutput: Poster

Samenvatting

Implicit motor sequence learning (IMSL) is affected in Parkinson disease (PD). Research in healthy young participants shows the potential for transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) to enhance IMSL. In PD, only null-effects have been reported to date.We determined concurrent, short-term and long-term effects of anodal tDCS over M1 on IMSL, as measured by the Serial Reaction Time (SRT) task, in persons with PD with mild cognitive impairment (MCI).Concurrent (anodal/sham tDCS intervention during the SRT-task), short-term (5- minutes post-intervention) and long-term (1-week post-intervention) effects on IMSL were evaluated in persons with idiopathic PD (Hoehn & Yahr stage II-III) with MCI. Results of 11 persons with PD (8 men, 3 women; mean age = 77.1 years; mean disease duration = 7.7 years) showed significant IMSL in the anodal (p=.016), but not in the sham tDCS condition (p=.937). Post-hoc analyses showed that IMSL reached statistical significance at 1-week post-intervention (p<.001).Anodal tDCS over M1 exerted beneficial effects on IMSL in persons with PD with MCI, in particular one week post-intervention. Our study is the first to report a positive effect of tDCS on IMSL in PD. Further research should include a larger, more cognitively diverse sample as well as additional follow-up periods.
Originele taal-2English
StatusPublished - 15 mei 2020
EvenementSynapsium Dondrite Conference on Cognitive Neuroscience - (Virtual), Nijmegen, Netherlands
Duur: 16 mei 202016 mei 2020

Conference

ConferenceSynapsium Dondrite Conference on Cognitive Neuroscience
LandNetherlands
StadNijmegen
Periode16/05/2016/05/20

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