Preliminary analysis of a randomized clinical trial comparing shoulder-arm morbidity between early breast cancer patients treated with short course image guided radiation therapy and conventional post surgery radiation therapy

Nele Adriaenssens; Hilde Van Parijs; Geertje Miedema; Truus Reynders; H. Versmessen; Mark De Ridder; Guy Storme; Pierre Lievens; Jan Lamote; Vincent Vinh - Hung

Preliminary analysis of a randomized clinical trial comparing shoulder-arm morbidity between early breast cancer patients treated with short course image guided radiation therapy and conventional post surgery radiation therapy

Nele Adriaenssens, Hilde Van Parijs, Geertje Miedema, Truus Reynders, H. Versmessen, Mark De Ridder, Guy Storme, Pierre Lievens, Jan Lamote, Vincent Vinh - Hung

Onderzoeksoutput: Article › peer review

Samenvatting

Amaç: Omuz/kol morbiditesi radyoterapinin (RT) ve meme cerrahisinin bilinen bir yan etkisidir. Fakat omuz/kol morbititesi için RT tekni?i seçiminin sonuçlar? aç?k bir ?ekilde tan?mlanmam??t?r. Bu çal??mada, erken meme kanserli hastalar?n omuz/kol morbiditesinin insidans? ve ayr?ca meme kanserine ba?l? kolun lenfödemi (MKBL) de muayene edildi ve konvansiyonel (KRT) ve k?sa süreli k?lavuz e?li?inde RT (KERT) tedavi tekniklerinin kar??la?t?r?lmas? amaçland?.
Hastalar ve Yöntem: 3 hafta postoperatif KERT ve 5-7 hafta KRT uygulanan hastalar? randomize ettik. Tomo Breast çal??mas?nda oldu?u gibi (onlar?n sonlan?m noktalar? kardiak ve pulmoner yan etkiler idi). MKBL ve omuz/kol morbiditesi ve MKBL RT'yi takiben bir ile üç ay aras?nda fiziksel fonksiyon ve common terminology criteria yan etki skalas? kullan?larak de?erlendirildi. Istatistiksel yöntem olarak ölçümler için t-test ve katagorik veriler için ki-kare testi kullan?ld?.
Bulgular: 91 hastan?n analizi sonucu en az bir omuz/kol morbiditesi ölçümü yan etki skalas?na göre skoru >% 80 deneyimli art?? ve % 18 oran?nda MKBL saptand?. Her iki kol hacmi anlaml? ölçüde artt? ve her iki kolda meydana gelen hareket k?s?tl?l??? anlaml? idi. Bununla birlikte iki tedavi grubunda MKBL insidans?nda veya omuz/kol morbiditesinde farkl?l?k anlaml? bulunmad?.
Sonuç: Tedaviden sonra bir ve üçüncü aylarda k?sa süreli KERT ile KRT kar??la?t?r?ld???nda omuz-kol morbiditesinde art?? saptanmad?. Uzun süreli takip gerekmesine ra?men sonuçlar k?sa süreli tedavi uygulamas?n? desteklemektedir. Kar?? taraf eksteremite morbiditesinin tesadüfi bir bulgu oldu?unu göstermek için daha fazla ara?t?rma gerekmektedir.

Originele taal-2	English
Pagina's (van-tot)	68-75
Aantal pagina's	8
Tijdschrift	Meme Sagligi Dergisi / Journal of Breast Health
Volume	8
Status	Published - 2012

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ANI47: Randomized trial comparing conventional vs short-course reduced volume conformal post-surgery radiation treatment in women with stage I or II breast cancer.
Storme, G. & Vinh - Hung, V.
1/01/07 → 31/12/09
Project: Fundamenteel

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Adriaenssens, N., Van Parijs, H., Miedema, G., Reynders, T., Versmessen, H., De Ridder, M., Storme, G., Lievens, P., Lamote, J., & Vinh - Hung, V. (2012). Preliminary analysis of a randomized clinical trial comparing shoulder-arm morbidity between early breast cancer patients treated with short course image guided radiation therapy and conventional post surgery radiation therapy. Meme Sagligi Dergisi / Journal of Breast Health, 8, 68-75.

Adriaenssens, Nele ; Van Parijs, Hilde ; Miedema, Geertje et al. / Preliminary analysis of a randomized clinical trial comparing shoulder-arm morbidity between early breast cancer patients treated with short course image guided radiation therapy and conventional post surgery radiation therapy. In: Meme Sagligi Dergisi / Journal of Breast Health. 2012 ; Vol. 8. blz. 68-75.

@article{efd13ee9dd5b43a5a98802f1ad4179cb,

title = "Preliminary analysis of a randomized clinical trial comparing shoulder-arm morbidity between early breast cancer patients treated with short course image guided radiation therapy and conventional post surgery radiation therapy",

abstract = "Purpose: Shoulder/arm morbidity is a known complication of breast cancer surgery and radiotherapy (RT), but the consequences of choosing one RT technology over another for shoulder/arm morbidity are not clearly defined. In this work, we examine early breast cancer patients to compare the incidence of shoulder/arm morbidity, including breast cancer related lymphedema (BCRL) of the arm, between conventional RT and short-course, image-guided RT (IGRT) treatments. Methods: We randomized patients between post-surgery IGRT over 3 weeks and conventional RT over 5 to 7 weeks, as part of the TomoBreast trial (whose primary endpoint was to assess pulmonary and cardiac toxicities). BCRL and shoulder/arm mobility were assessed prior to and between one and three months following RT, using physical function assessment and common terminology criteria for adverse events. Intention to treat analyses used the matched-pairs t-test for continuous measurements and the chi-squared test for categorical data. Results: Analysis of the first 91 evaluable patients found that >80% experienced increase in adverse event score in at least one shoulder/arm mobility measurement, and 18% had BCRL symptoms. Arm volume on both sides significantly increased and significant impairment of movement occurred in both limbs. However, there was no significant difference in BCRL incidence or shoulder/arm mobility impairment between the treatment groups. Conclusion: One to three months after treatment, short-course IGRT had not increased shoulder/arm morbidity compared with conventional RT. Although confirmation requires a longer follow-up, the results support the use of a short-course schedule. The incidental finding that morbidity affected the contralateral limb warrants further investigation.",

keywords = "clinical trials, randomized, shoulder, arm, morbidity, lymphedema, radiotherapy",

author = "Nele Adriaenssens and {Van Parijs}, Hilde and Geertje Miedema and Truus Reynders and H. Versmessen and {De Ridder}, Mark and Guy Storme and Pierre Lievens and Jan Lamote and {Vinh - Hung}, Vincent",

year = "2012",

language = "English",

volume = "8",

pages = "68--75",

journal = "Meme Sagligi Dergisi / Journal of Breast Health",

issn = "1306-0945",

publisher = "Federation of Breast Diseases Society",

}

Adriaenssens, N, Van Parijs, H, Miedema, G, Reynders, T, Versmessen, H, De Ridder, M , Storme, G , Lievens, P , Lamote, J & Vinh - Hung, V 2012, 'Preliminary analysis of a randomized clinical trial comparing shoulder-arm morbidity between early breast cancer patients treated with short course image guided radiation therapy and conventional post surgery radiation therapy', Meme Sagligi Dergisi / Journal of Breast Health, vol. 8, blz. 68-75.

Preliminary analysis of a randomized clinical trial comparing shoulder-arm morbidity between early breast cancer patients treated with short course image guided radiation therapy and conventional post surgery radiation therapy. / Adriaenssens, Nele; Van Parijs, Hilde; Miedema, Geertje et al.
In: Meme Sagligi Dergisi / Journal of Breast Health, Vol. 8, 2012, blz. 68-75.

Onderzoeksoutput: Article › peer review

TY - JOUR

T1 - Preliminary analysis of a randomized clinical trial comparing shoulder-arm morbidity between early breast cancer patients treated with short course image guided radiation therapy and conventional post surgery radiation therapy

AU - Adriaenssens, Nele

AU - Van Parijs, Hilde

AU - Miedema, Geertje

AU - Reynders, Truus

AU - Versmessen, H.

AU - De Ridder, Mark

AU - Storme, Guy

AU - Lievens, Pierre

AU - Lamote, Jan

AU - Vinh - Hung, Vincent

PY - 2012

Y1 - 2012

N2 - Purpose: Shoulder/arm morbidity is a known complication of breast cancer surgery and radiotherapy (RT), but the consequences of choosing one RT technology over another for shoulder/arm morbidity are not clearly defined. In this work, we examine early breast cancer patients to compare the incidence of shoulder/arm morbidity, including breast cancer related lymphedema (BCRL) of the arm, between conventional RT and short-course, image-guided RT (IGRT) treatments. Methods: We randomized patients between post-surgery IGRT over 3 weeks and conventional RT over 5 to 7 weeks, as part of the TomoBreast trial (whose primary endpoint was to assess pulmonary and cardiac toxicities). BCRL and shoulder/arm mobility were assessed prior to and between one and three months following RT, using physical function assessment and common terminology criteria for adverse events. Intention to treat analyses used the matched-pairs t-test for continuous measurements and the chi-squared test for categorical data. Results: Analysis of the first 91 evaluable patients found that >80% experienced increase in adverse event score in at least one shoulder/arm mobility measurement, and 18% had BCRL symptoms. Arm volume on both sides significantly increased and significant impairment of movement occurred in both limbs. However, there was no significant difference in BCRL incidence or shoulder/arm mobility impairment between the treatment groups. Conclusion: One to three months after treatment, short-course IGRT had not increased shoulder/arm morbidity compared with conventional RT. Although confirmation requires a longer follow-up, the results support the use of a short-course schedule. The incidental finding that morbidity affected the contralateral limb warrants further investigation.

AB - Purpose: Shoulder/arm morbidity is a known complication of breast cancer surgery and radiotherapy (RT), but the consequences of choosing one RT technology over another for shoulder/arm morbidity are not clearly defined. In this work, we examine early breast cancer patients to compare the incidence of shoulder/arm morbidity, including breast cancer related lymphedema (BCRL) of the arm, between conventional RT and short-course, image-guided RT (IGRT) treatments. Methods: We randomized patients between post-surgery IGRT over 3 weeks and conventional RT over 5 to 7 weeks, as part of the TomoBreast trial (whose primary endpoint was to assess pulmonary and cardiac toxicities). BCRL and shoulder/arm mobility were assessed prior to and between one and three months following RT, using physical function assessment and common terminology criteria for adverse events. Intention to treat analyses used the matched-pairs t-test for continuous measurements and the chi-squared test for categorical data. Results: Analysis of the first 91 evaluable patients found that >80% experienced increase in adverse event score in at least one shoulder/arm mobility measurement, and 18% had BCRL symptoms. Arm volume on both sides significantly increased and significant impairment of movement occurred in both limbs. However, there was no significant difference in BCRL incidence or shoulder/arm mobility impairment between the treatment groups. Conclusion: One to three months after treatment, short-course IGRT had not increased shoulder/arm morbidity compared with conventional RT. Although confirmation requires a longer follow-up, the results support the use of a short-course schedule. The incidental finding that morbidity affected the contralateral limb warrants further investigation.

KW - clinical trials

KW - randomized

KW - shoulder

KW - arm

KW - morbidity

KW - lymphedema

KW - radiotherapy

M3 - Article

SN - 1306-0945

VL - 8

SP - 68

EP - 75

JO - Meme Sagligi Dergisi / Journal of Breast Health

JF - Meme Sagligi Dergisi / Journal of Breast Health

ER -

Adriaenssens N, Van Parijs H, Miedema G, Reynders T, Versmessen H, De Ridder M et al. Preliminary analysis of a randomized clinical trial comparing shoulder-arm morbidity between early breast cancer patients treated with short course image guided radiation therapy and conventional post surgery radiation therapy. Meme Sagligi Dergisi / Journal of Breast Health. 2012;8:68-75.

Preliminary analysis of a randomized clinical trial comparing shoulder-arm morbidity between early breast cancer patients treated with short course image guided radiation therapy and conventional post surgery radiation therapy

Samenvatting

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Projecten

ANI47: Randomized trial comparing conventional vs short-course reduced volume conformal post-surgery radiation treatment in women with stage I or II breast cancer.

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