Prevalence and epidemiology of HIV type 1 drug resistance among newly diagnosed therapy-naive patients in Belgium from 2003 to 2006

Jurgen Vercauteren, I Derdelinckx, Andre Sasse, M. Bogaert, H Ceunen, A De Roo, Stephane De Wit, K Deforche, Fedoua Echahidi, K. Fransen, Jc Goffard, P. Goubau, E Goudeseune, Jc Yombi, Patrick Lacor, C. Liesnard, M Moutschen, Denis Pierard, R Rens, Y SchrootenD. Vaira, Annelies Van Den Heuvel, B Van Der Gucht, M. Van Ranst, Sigi Van Wijngaerden, B Vandercam, Marc Vekemans, C. Verhofstede, N. Clumeck, A. Vandamme, K. Van Laethem

Onderzoeksoutput: Articlepeer review

29 Citaten (Scopus)

Samenvatting

This study is the first prospective study to assess the prevalence, epidemiology,
and risk factors of HIV-1 drug resistance in newly diagnosed HIV-infected
patients in Belgium. In January 2003 it was initiated as part of the pan-European
SPREAD program, and continued thereafter for four inclusion rounds until December
2006. Epidemiological, clinical, and behavioral data were collected using a
standardized questionnaire and genotypic resistance testing was done on a sample
taken within 6 months of diagnosis. Two hundred and eighty-five patients were
included. The overall prevalence of transmitted HIV-1 drug resistance in Belgium
was 9.5% (27/285, 95% CI: 6.6-13.4). Being infected in Belgium, which largely
coincided with harboring a subtype B virus, was found to be significantly
associated with transmission of drug resistance. The relatively high rate of
baseline resistance might jeopardize the success of first line treatment as more
than 1 out of 10 (30/285, 10.5%) viruses did not score as fully susceptible to
one of the recommended first-line regimens, i.e., zidovudine, lamivudine, and
efavirenz. Our results support the implementation of genotypic resistance testing
as a standard of care in all treatment-naive patients in Belgium.
Originele taal-2English
Pagina's (van-tot)355-362
Aantal pagina's8
TijdschriftAIDS Res Hum Retroviruses
Volume24
StatusPublished - 2008

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