Prognostic Value of Programmed Electrical Stimulation in Brugada Syndrome: 20 Years Experience

Juan Sieira, Giulio Conte, Giuseppe Ciconte, Carlo de Asmundis, Jean-Baptiste Chierchia, Giannis Baltogiannis, Giacomo Di Giovanni, Yukio Saitoh, Ghazala Irfan, Ruben Casado-Arroyo, Justo Julià, Mark La Meir, Francis Wellens, Kristel Wauters, Sophie Van Malderen, Gudrun Pappaert, Pedro Brugada

Onderzoeksoutput: Articlepeer review

85 Citaten (Scopus)


BACKGROUND: -The prognostic value of electrophysiological investigations in individuals with Brugada syndrome remains controversial. Different groups have published contradictory data. Long-term follow up is needed to clarify this issue.

METHODS AND RESULTS: -Patients presenting with spontaneous or drug-induced Brugada type I electrocardiogram (ECG) and in whom PES was performed at our institution were considered eligible for this study. A total of 403 consecutive patients (235 males, 58.2%; mean age: 43.2±16.2 years) were included. VA during PES were induced in 73 (18.1%) patients. After a mean follow-up time of 74.3±57.3 months, (median 57.3), 25 arrhythmic events occurred (16 in the inducible group and 9 in the non inducible). VA inducibility presented a hazard ratio for events of 8.3 (95% CI 3.6 - 19.4), p<0.01.

CONCLUSIONS: -Programmed ventricular stimulation of the heart is a good predictor of outcome in individuals with Brugada syndrome. It might be of special value to guide further management when performed in asymptomatic individuals. The over- all accuracy of the test makes it a suitable screening tool to reassure non-inducible asymptomatic individuals.

Originele taal-2English
Pagina's (van-tot)777-784
Aantal pagina's8
TijdschriftCirculation: Arrhythmia and Electrophysiology
Nummer van het tijdschrift4
Vroegere onlinedatum22 apr 2015
StatusPublished - 2015


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