@article{bbde6e99f0634caab60fd1c0b732ee75,
title = "Prognostic Value of Programmed Electrical Stimulation in Brugada Syndrome: 20 Years Experience",
abstract = "BACKGROUND: -The prognostic value of electrophysiological investigations in individuals with Brugada syndrome remains controversial. Different groups have published contradictory data. Long-term follow up is needed to clarify this issue.METHODS AND RESULTS: -Patients presenting with spontaneous or drug-induced Brugada type I electrocardiogram (ECG) and in whom PES was performed at our institution were considered eligible for this study. A total of 403 consecutive patients (235 males, 58.2%; mean age: 43.2±16.2 years) were included. VA during PES were induced in 73 (18.1%) patients. After a mean follow-up time of 74.3±57.3 months, (median 57.3), 25 arrhythmic events occurred (16 in the inducible group and 9 in the non inducible). VA inducibility presented a hazard ratio for events of 8.3 (95% CI 3.6 - 19.4), p<0.01.CONCLUSIONS: -Programmed ventricular stimulation of the heart is a good predictor of outcome in individuals with Brugada syndrome. It might be of special value to guide further management when performed in asymptomatic individuals. The over- all accuracy of the test makes it a suitable screening tool to reassure non-inducible asymptomatic individuals.",
keywords = "arrhythmias, Brugada syndrome, cardiac, electrophysiology, prognosis, implantable cardioverter defibrillator, ajmaline, flecainide, procainamide, acute heart infarction, adolescent, adult, aged, article, atrial fibrillation, cardiogenic shock, cause of death, child, device infection, ECG abnormality, electrocardiogram, electrostimulation, event free survival, faintness, female, follow up, heart electrophysiology, heart rupture, heart stimulation, heart supraventricular arrhythmia, heart ventricle arrhythmia, heart ventricle extrasystole, human, lead dislocation, lead fracture, major clinical study, male, medical device complication, pacemaker implantation, predictive value, priority journal, programmed electrical stimulation, prospective study, pulse generator migration, QT prolongation, second degree atrioventricular block, septic shock, sinus node disease, sinus tachycardia, ST segment elevation, T wave, very elderly",
author = "Juan Sieira and Giulio Conte and Giuseppe Ciconte and {De Asmundis}, Carlo and Gian-Battista Chierchia and Giannis Baltogiannis and {Di Giovanni}, Giacomo and Yukio Saitoh and Ghazala Irfan and Ruben Casado-Arroyo and Justo Juli{\'a} and {La Meir}, Mark and Francis Wellens and Kristel Wauters and {Van Malderen}, Sophie and Gudrun Pappaert and Pedro Brugada",
year = "2015",
month = aug,
day = "22",
doi = "10.1161/CIRCEP.114.002647",
language = "English",
volume = "8",
pages = "777--784",
journal = "Circulation: Arrhythmia and Electrophysiology",
issn = "1941-3149",
publisher = "Lippincott Williams and Wilkins",
number = "4",
}