Methods 24 BS patients (mean age 44.0 ± 14.1 years, 50.0% males) with (likely) pathogenic SCN5A variants were enrolled in this cross-sectional study. They were divided into T-carriers (n = 13) and M-carriers (n = 11). Using Tissue Velocity Imaging (TVI), the ejection delay of the RV (RVED, in ms) was measured as the time from the QRS onset to the onset of the systolic ejection wave at the end of the isovolumetric contraction (IVC).
Results T-carriers demonstrated longer RVED’s com- pared tot M-carriers (139.3±15.1 vs 123.0±11.5 ms, P = 0.007).
Conclusion This is the first report, using non-invasive TVI, to demonstrate that BS patients carrying T-var- iants have longer RVED’s indicating a more severe pheno- type. Given that RVED represents conduction delay, we provide additional evidence to further support the depolarization hypothesis in BS.
|Titel||Arrhythmias for every Cardiologist|
|Status||Published - 8 okt 2015|
|Evenement||9th Belgian Heart Rhythm Meeting - Sheraton Brussels Airport, Hotel and Congress Centre, Brussels, Belgium|
Duur: 8 okt 2015 → 9 okt 2015
|Conference||9th Belgian Heart Rhythm Meeting|
|Periode||8/10/15 → 9/10/15|