Protein sulfenic acid formation: from cellular damage to redox regulation

Goedele Roos, Joris Messens

Onderzoeksoutput: Scientific reviewpeer review

216 Citaten (Scopus)

Samenvatting

Protein sulfenic acid formation has long been regarded as unwanted damage caused by reactive oxygen species (ROS). However, over the past 10 years, accumulating evidence has shown that the reversible oxidation of cysteine thiol groups to sulfenic acid functions as a redox-based signal transduction mechanism. Here, we review the mechanisms of sulfenic acid formation by ROS. We present some of the most important roles played by sulfenic acids in living cells as well as the pathways that regulate sulfenic acid formation. We highlight the experimental tools that have been developed to study the cellular sulfenome and show how computational approaches might help to better understand the mechanisms of sulfenic acid formation.

Originele taal-2English
Pagina's (van-tot)314-326
Aantal pagina's13
TijdschriftFree Radical Biology & Medicine
Volume51
Nummer van het tijdschrift2
DOI's
StatusPublished - 15 jul 2011

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