Projecten per jaar
Samenvatting
Connexin proteins are abundantly present in the digestive system. They primarily form gap junctions, which control the intercellular exchange of critical homeostasis regulators. By doing so, gap junctions drive a plethora of gastrointestinal and hepatic functional features, including gastric and gut motility, gastric acid secretion, intestinal innate immune defense, xenobiotic biotransformation, glycogenolysis, bile secretion, ammonia detoxification and plasma protein synthesis. In the last decade, it has become clear that connexin hemichannels, which are the structural precursors of gap junctions, also provide a pathway for cellular communication, namely between the cytosol and the extracellular environment. Although merely pathological functions have been described, some physiological roles have been attributed to connexin hemichannels, in particular in the modulation of colonic motility. This equally holds true for cellular channels composed of pannexins, connexin-like proteins recently identified in the intestine and the liver, which have become acknowledged key players in inflammatory processes and that have been proposed to control colonic motility, secretion and blood flow.
Originele taal-2 | English |
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Pagina's (van-tot) | 2809-2821 |
Aantal pagina's | 13 |
Tijdschrift | Cellular and Molecular Life Sciences |
Volume | 72 |
Nummer van het tijdschrift | 15 |
Vroegere onlinedatum | 18 jun 2015 |
DOI's | |
Status | Published - 1 aug 2015 |
Vingerafdruk
Duik in de onderzoeksthema's van 'Roles of connexins and pannexins in digestive homeostasis'. Samen vormen ze een unieke vingerafdruk.-
OZR2651: Internationale alliantie-onderzoeksgroep: hepatische connexines en pannexines
Vinken, M., Rogiers, V., Cogliati, B. & Dagli, M. L.
1/08/14 → 1/07/26
Project: Fundamenteel
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Onderzoekersoutput
- 29 Citaties
- 2 Article
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Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity
Maes, M., McGill, M. R., da Silva, T. C., Abels, C., Lebofsky, M., Weemhoff, J. L., Tiburcio, T., Veloso Alves Pereira, I., Willebrords, J., Crespo Yanguas, S., Farhood, A., Beschin, A., Van Ginderachter, J. A., Penuela, S., Jaeschke, H., Cogliati, B. & Vinken, M., 1 mei 2017, In: Archives of Toxicology. 91, 5, blz. 2245-2261 17 blz.Onderzoeksoutput: Article › peer review
17 Citaten (Scopus) -
Connexins and pannexins in liver damage
Crespo Yanguas, S., Willebrords, J., Maes, M., da Silva, T. C., Alves Pereira, I. V., Cogliati, B., Zaidan Dagli, M. L. & Vinken, M., 18 feb 2016, In: EXCLI Journal. 15, blz. 177-186 10 blz.Onderzoeksoutput: Article › peer review
Activiteiten
- 1 Talk or presentation at a workshop/seminar
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The role of connexins, pannexins and their channels in liver fibrosis
Sara Crespo Yanguas (Speaker)
28 nov 2018Activiteit: Talk or presentation at a workshop/seminar