Safety of Cultivated Limbal Epithelial Stem Cell Transplantation for Human Corneal Regeneration

Joséphine Behaegel, S. Ní Dhubhghaill, C. Koppen, N. Zakaria

Onderzoeksoutput: Articlepeer review

29 Citaten (Scopus)

Samenvatting

Ex vivo cultivated limbal stem cell transplantation is a promising technique for the treatment of limbal stem cell deficiency. While the results of the clinical trials have been extensively reported since the introduction of the technique in 1997, little has been reported regarding the potential health risks associated with production processes and transplantation techniques. Culture procedures require the use of animal and/or human-derived products, which carry the potential of introducing toxic or infectious agents through contamination with known or unknown additives. Protocols vary widely, and the risks depend on the local institutional methods. Good manufacturing practice and xeno-free culture protocols could reduce potential health risks but are not yet a common practice worldwide. In this review, we focus on the safety of both autologous- and allogeneic-cultivated limbal stem cell transplantation, with respect to culture processes, surgical approaches, and postoperative strategies.

Originele taal-2English
Artikelnummer6978253
Pagina's (van-tot)6978253
Aantal pagina's11
TijdschriftStem Cells International
Volume2017
DOI's
StatusPublished - 2017

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