Painful instability due to proximal migration of the first metacarpal remains a challenging problem in patients who have undergone multiple surgeries for trapeziometacarpal osteoarthritis. The objective of this study was to investigate whether scaphometacarpal (SMC) arthrodesis with a structural bone graft is an acceptable and definitive salvage procedure for the multioperated patient. Three patients underwent SMC arthrodesis using a structural iliac crest bone graft. All patients had symptomatic instability of the thumb base and had undergone three to four surgeries prior to the arthrodesis. All patients were satisfied with the outcomes. Mean opposition decreased from 8 to 7 and mean retropulsion remained at 1. Mean grip strength increased from 3.5 to 10.5kg and mean precision pinch strength increased from 1.5 to 2.5kg. Fusion was confirmed in all patients. SMC arthrodesis with a structural bone graft is an acceptable procedure that largely preserves thumb opposition and restores stability with increased grip and pinch strength. Although far from ideal, it can be considered as a definitive salvage procedure in patients who have already had multiple surgeries to the trapeziometacarpal joint.