Secondary Metabolites Isolated from Artemisia afra and Artemisia annua and Their Anti-Malarial, Anti-Inflammatory and Immunomodulating Properties-Pharmacokinetics and Pharmacodynamics: A Review

Lahngong Methodius Shinyuy, Gisèle E Loe, Olivia Jansen, Lúcia Mamede, Allison Ledoux, Sandra Fankem Noukimi, Suh Nchang Abenwie, Stephen Mbigha Ghogomu, Jacob Souopgui, Annie Robert, Kristiaan Demeyer, Michel Frederich

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Samenvatting

There are over 500 species of the genus Artemisia in the Asteraceae family distributed over the globe, with varying potentials to treat different ailments. Following the isolation of artemisinin (a potent anti-malarial compound with a sesquiterpene backbone) from Artemisia annua, the phytochemical composition of this species has been of interest over recent decades. Additionally, the number of phytochemical investigations of other species, including those of Artemisia afra in a search for new molecules with pharmacological potentials, has increased in recent years. This has led to the isolation of several compounds from both species, including a majority of monoterpenes, sesquiterpenes, and polyphenols with varying pharmacological activities. This review aims to discuss the most important compounds present in both plant species with anti-malarial properties, anti-inflammatory potentials, and immunomodulating properties, with an emphasis on their pharmacokinetics and pharmacodynamics properties. Additionally, the toxicity of both plants and their anti-malaria properties, including those of other species in the genus Artemisia, is discussed. As such, data were collected via a thorough literature search in web databases, such as ResearchGate, ScienceDirect, Google scholar, PubMed, Phytochemical and Ethnobotanical databases, up to 2022. A distinction was made between compounds involved in a direct anti-plasmodial activity and those expressing anti-inflammatory and immunomodulating activities or anti-fever properties. For pharmacokinetics activities, a distinction was made between compounds influencing bioavailability (CYP effect or P-Glycoprotein effect) and those affecting the stability of pharmacodynamic active components.

Originele taal-2English
Artikelnummer613
Aantal pagina's27
TijdschriftMetabolites
Volume13
Nummer van het tijdschrift5
DOI's
StatusPublished - 29 apr 2023

Bibliografische nota

Funding Information:
This research received funds from Académie de Recherche et d’Enseignement Supérieur (ARES-CCD), Rue Royale 180,1000 Bruxelles, Belgium. Grant number: PRD-PFS 2020.

Publisher Copyright:
© 2023 by the authors.

Copyright:
Copyright 2023 Elsevier B.V., All rights reserved.

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