TY - JOUR
T1 - Self-sampling to improve cervical cancer screening coverage in Switzerland
T2 - a randomised controlled trial
AU - Viviano, Manuela
AU - Catarino, Rosa
AU - Jeannot, Emilien
AU - Boulvain, Michel
AU - Malinverno, Manuela Undurraga
AU - Vassilakos, Pierre
AU - Petignat, Patrick
PY - 2017
Y1 - 2017
N2 - BACKGROUND: The aim of this study is to evaluate whether self-sampling can increase screening attendance of women who do not attend regular screening in Switzerland.METHODS: Participants were proactively recruited in Geneva between September 2011 and November 2015. Women (25-69 years) who had not undergone CC screening in the last 3 years were considered eligible. Through a 1 : 1 ratio randomisation, enrolled participants were invited to either undergo liquid-based cytology, which was performed by a health-care provider (control group, CG) or to take a self-sample for HPV-testing, which was mailed to their home (intervention group, IG).RESULTS: A total of 331 and 336 women were randomised in the CG and in the IG, respectively. Overall, 7.3% (95% CI: 4.9-10.6) women in the CG and 5.7% (95% CI: 3.6-8.7) women in the IG did not undergo the initial screening (P=0.400). There were 1.95% (95% CI: 0.8-4.3) women in the CG and 5.05% (95% CI: 3.1-8.1) women in the IG with a positive screen who did not attend triage and colposcopy (P=0.036).CONCLUSIONS: The participation in CC screening in women offered self-sampling was not higher than among those offered specimen collection by a clinician. Compliance with further follow-up for women with a positive HPV test on the self-sample requires further attention.
AB - BACKGROUND: The aim of this study is to evaluate whether self-sampling can increase screening attendance of women who do not attend regular screening in Switzerland.METHODS: Participants were proactively recruited in Geneva between September 2011 and November 2015. Women (25-69 years) who had not undergone CC screening in the last 3 years were considered eligible. Through a 1 : 1 ratio randomisation, enrolled participants were invited to either undergo liquid-based cytology, which was performed by a health-care provider (control group, CG) or to take a self-sample for HPV-testing, which was mailed to their home (intervention group, IG).RESULTS: A total of 331 and 336 women were randomised in the CG and in the IG, respectively. Overall, 7.3% (95% CI: 4.9-10.6) women in the CG and 5.7% (95% CI: 3.6-8.7) women in the IG did not undergo the initial screening (P=0.400). There were 1.95% (95% CI: 0.8-4.3) women in the CG and 5.05% (95% CI: 3.1-8.1) women in the IG with a positive screen who did not attend triage and colposcopy (P=0.036).CONCLUSIONS: The participation in CC screening in women offered self-sampling was not higher than among those offered specimen collection by a clinician. Compliance with further follow-up for women with a positive HPV test on the self-sample requires further attention.
KW - Adult
KW - Atypical Squamous Cells of the Cervix
KW - Colposcopy/statistics & numerical data
KW - Early Detection of Cancer/methods
KW - Female
KW - Humans
KW - Middle Aged
KW - Papillomavirus Infections/diagnosis
KW - Patient Acceptance of Health Care/statistics & numerical data
KW - Self Care
KW - Specimen Handling
KW - Switzerland
KW - Triage/statistics & numerical data
KW - Uterine Cervical Neoplasms/diagnosis
KW - Uterine Cervical Dysplasia/diagnosis
U2 - 10.1038/bjc.2017.111
DO - 10.1038/bjc.2017.111
M3 - Article
C2 - 28427086
SN - 0007-0920
VL - 116
SP - 1382
EP - 1388
JO - British Journal of Cancer
JF - British Journal of Cancer
IS - 11
ER -