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Background: Nocturnal cerebrospinal fluid (CSF) and blood melatonin levels are altered in Alzheimer's disease (AD). However, literature remains inconclusive on daytime blood melatonin levels. A positive correlation between melatonin levels and Mini-Mental State Examination (MMSE) scores in AD subjects has been evidenced following cross-sectional analyses. Whereas a correlation between serum and spinal CSF melatonin has been shown in healthy volunteers, an equal investigation in AD patients still has to be undertaken.
Objective: 1) To evaluate whether serum melatonin levels correlate with spinal CSF melatonin levels in AD. 2) To compare daytime CSF and serum melatonin levels between patients with AD dementia, mild cognitive impairment due to AD, and healthy controls, and to evaluate whether melatonin can affect cognitive decline in AD.
Methods: Subjects with AD and healthy controls included in two existing cohorts, of whom a CSF and serum sample was available at the neurobiobank and had at least 6 months of neuropsychological follow-up, were included in the present study. Melatonin concentrations were measured with liquid chromatography-mass spectrometry.
Results: Daytime serum melatonin levels correlated with spinal CSF melatonin levels in AD (r = 0.751, p < 0.001). No significant differences regarding daytime melatonin levels were found between patients and controls. No correlations were observed between daytime melatonin levels and MMSE score changes.
Conclusion: Daytime serum melatonin accurately reflects CSF melatonin levels in AD, raising the possibility to assess melatonin alterations by solely performing blood sampling if also confirmed for night-time values. However, daytime melatonin levels are not associated with changes of cognitive impairment.
Originele taal-2 | English |
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Pagina's (van-tot) | 693-704 |
Aantal pagina's | 12 |
Tijdschrift | Journal of Alzheimer's Disease |
Volume | 83 |
Nummer van het tijdschrift | 2 |
DOI's | |
Status | Published - 2 aug 2021 |
Bibliografische nota
Funding Information:This work was supported by Fonds Wetenschappelijk Onderzoek (FWO), Flanders, grant number B040419N and Vrije Universtiteit Brussel (VUB) OZR Back-up Mandate (OZR3629).
Funding Information:
Serum daytime melatonin levels accurately reflect daytime CSF melatonin levels in the AD continuum, expressing the possibility to use blood sampling when studying melatonin’s disruptions and effects in AD. However, the correlation between night-time blood and CSF melatonin values remains to be proven. The sole need of blood for melatonin measurement in AD would bring along several advantages, because venipuncture is less invasive and easier performed in dark environment than lumbar puncture. Furthermore, there is a possibility to collect multiple blood samples within a 24-h period. We conclude from This work was supported by Fonds Wetenschap-pelijk Onderzoek (FWO), Flanders, grant number B040419N and Vrije Universtiteit Brussel (VUB) OZR Back-up Mandate (OZR3629). The funders had no role in study design, data collection, data analysis or interpretation of the data, nor in the writing of the report or decision to submit the article for publication. Published with support of ‘Universitaire Stichting’ of Belgium.
Publisher Copyright:
© 2021 - The authors.
Copyright:
Copyright 2022 Elsevier B.V., All rights reserved.
Vingerafdruk
Duik in de onderzoeksthema's van 'Serum Daytime Melatonin Levels Reflect Cerebrospinal Fluid Melatonin Levels in Alzheimer's Disease but Are Not Correlated with Cognitive Decline'. Samen vormen ze een unieke vingerafdruk.Projecten
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OZR3528: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - UAntwerpen, NOUS Amber
5/03/20 → 4/03/24
Project: Fundamenteel
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FWOAL927: Kunnen antiepileptogene behandelingen de progressie van de ziekte van Alzheimer afremmen?
Smolders, I., Engelborghs, S. & Versijpt, J.
1/01/19 → 31/12/22
Project: Fundamenteel