Signal representation and processing of nucleotide sequences

Paul Cristea, Rodica Tuduce, Iulian Nastac, Jan Cornelis, Rudi Deklerck, Marius Andrei

Onderzoeksoutput: Articlepeer review

5 Citaten (Scopus)


Sets of related signals can be represented by separating their joint
variation and showing the individual signal offsets with respect to this
reference. An example is the Genomic Signal Analysis (GSA) of pathogen
variability. The conversion of symbolic nucleotide sequences to genomic
signals allows to use signal processing methods to analyse genomic data.
This approach reveals striking regularities in the distribution of nucleotides and
pair of nucleotides along the sequences, in both prokaryotes and eukaryotes.
Genomic signals can also be used for sequence prediction, similarly to time
series prediction. The methodology is also adequate for studying the
development of pathogen multiple resistance to drugs.
Originele taal-2English
Pagina's (van-tot)253-268
Aantal pagina's16
TijdschriftInternational Journal of Functional Informatics and Personalised Medicine
Nummer van het tijdschrift3
StatusPublished - 2008


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