Thanks to chemo- and radiotherapy the life expectancy for children with cancer has increased considerably. However, these cancer treatments may have serious side effects, sterility being an important one. Adult men have the possibility to circumvent this side effect by banking their semen. Prepubertal boys, however, can not benefit from this option, because spermatogenesis has not been initiated yet. A possible solution to preserve their fertility is banking and transplanting the precursor cells of spermatogenesis, i.e. the spermatogonial stem cells or SSCs. Since the first report of this model in 1994, a lot of progress has been made. However, before spermatogonial stem cell transplantation (SSCT) can be offered in a clinical setting, both the efficiency and safety of the technique has to be guaranteed. This presentation overviews the studies that have been carried out in this regard.
|Status||Published - 24 mei 2012|