Strategies, models and biomarkers in experimental non-alcoholic fatty liver disease research

Joost Willebrords, Isabel Veloso Alves Pereira, Michaël Maes, Sara Crespo Yanguas, Isabelle Colle, Bert Van den Bossche, Tereza Cristina da Silva, Claudia Pinto Marques Souza de Oliveira, Wellington Andraus, Venâncio Avancini Ferreira Alves, Bruno Cogliati, Mathieu Vinken

Onderzoeksoutput: Articlepeer review

142 Citaten (Scopus)

Samenvatting

Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of liver diseases, including simple steatosis, steatohepatitis, liver fibrosis and cirrhosis and hepatocellular carcinoma. NAFLD is currently the most dominant chronic liver disease in Western countries due to the fact that hepatic steatosis is associated with insulin resistance, type 2 diabetes mellitus, obesity, metabolic syndrome and drug-induced injury. A variety of chemicals, mainly drugs, and diets is known to cause hepatic steatosis in humans and rodents. Experimental NAFLD models rely on the application of a diet or the administration of drugs to laboratory animals or the exposure of hepatic cell lines to these drugs. More recently, genetically modified rodents or zebrafish have been introduced as NAFLD models. Considerable interest now lies in the discovery and development of novel non-invasive biomarkers of non-alcoholic fatty liver disease, with specific focus on hepatic steatosis. Experimental diagnostic biomarkers of NAFLD, such as (epi)genetic parameters and ‘-omics’-based read-outs are still in their infancy, but show great promise. . In this paper, the array of tools and models for the study of liver steatosis is discussed. Furthermore, the current state-of-art regarding experimental biomarkers such as epigenetic, genetic, transcriptomic, proteomic and metabonomic biomarkers will be reviewed.
Originele taal-2English
Pagina's (van-tot)106-125
Aantal pagina's20
TijdschriftProgress in Lipid Research
Volume59
DOI's
StatusPublished - 1 jul 2015

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