TY - JOUR
T1 - Temperature analysis of 3D-printed biomaterials during unipolar and bipolar radiofrequency ablation procedure
AU - Cappello, Ida Anna
AU - Candelari, Mara
AU - Pannone, Luigi
AU - Monaco, Cinzia
AU - Bori, Edoardo
AU - Talevi, Giacomo
AU - Ramak, Robbert
AU - La Meir, Mark
AU - Gharaviri, Ali
AU - Chierchia, Gian Battista
AU - Innocenti, Bernardo
AU - de Asmundis, Carlo
N1 - Publisher Copyright:
Copyright © 2022 Cappello, Candelari, Pannone, Monaco, Bori, Talevi, Ramak, La Meir, Gharaviri, Chierchia, Innocenti and de Asmundis.
Copyright:
Copyright 2022 Elsevier B.V., All rights reserved.
PY - 2022/9/14
Y1 - 2022/9/14
N2 - Background: Due to their mechanical properties, the MED625FLX and TPU95A could be appropriate candidates for cardiac 3D surgical guide use during radiofrequency ablation (RFA) treatment. Methods: RFA aims to destroy the heart tissue, which cause arrhythmias, by applying a radiofrequency (RF) energy at critical temperature above +50.0°C, where the thermal damage is considered not reversible. This study aims to analyze the biomaterials thermal properties with different thicknesses, by testing the response to bipolar and unipolar RFA on porcine muscle samples (PMS), expressed in temperature. For the materials evaluation, the tissue temperature during RFA applications was recorded, firstly without (control) and after with the biomaterials in position. The biomaterials were considered suitable for the RFA treatment if: (1) the PMS temperatures with the samples were not statistically different compared with the control; (2) the temperatures never reached the threshold; (3) no geometrical changes after RFA were observed. Results: Based on these criteria, none of the tested biomaterials resulted appropriate for unipolar RFA and the TPU95A failed almost all thermal tests also with the bipolar RFA. The 1.0 mm MED625FLX was modified by bipolar RFA in shape, losing its function. Instead, the 2.5 mm MED625FLX was considered suitable for bipolar RFA catheter use only. Conclusions: The 2.5 mm MED625FLX could be used, in the design of surgical guides for RFA bipolar catheter only, because of mechanical, geometrical, and thermal properties. None of biomaterials tested are appropriate for unipolar ablation catheter because of temperature concerns. Further investigations for clinical use are eagerly awaited.
AB - Background: Due to their mechanical properties, the MED625FLX and TPU95A could be appropriate candidates for cardiac 3D surgical guide use during radiofrequency ablation (RFA) treatment. Methods: RFA aims to destroy the heart tissue, which cause arrhythmias, by applying a radiofrequency (RF) energy at critical temperature above +50.0°C, where the thermal damage is considered not reversible. This study aims to analyze the biomaterials thermal properties with different thicknesses, by testing the response to bipolar and unipolar RFA on porcine muscle samples (PMS), expressed in temperature. For the materials evaluation, the tissue temperature during RFA applications was recorded, firstly without (control) and after with the biomaterials in position. The biomaterials were considered suitable for the RFA treatment if: (1) the PMS temperatures with the samples were not statistically different compared with the control; (2) the temperatures never reached the threshold; (3) no geometrical changes after RFA were observed. Results: Based on these criteria, none of the tested biomaterials resulted appropriate for unipolar RFA and the TPU95A failed almost all thermal tests also with the bipolar RFA. The 1.0 mm MED625FLX was modified by bipolar RFA in shape, losing its function. Instead, the 2.5 mm MED625FLX was considered suitable for bipolar RFA catheter use only. Conclusions: The 2.5 mm MED625FLX could be used, in the design of surgical guides for RFA bipolar catheter only, because of mechanical, geometrical, and thermal properties. None of biomaterials tested are appropriate for unipolar ablation catheter because of temperature concerns. Further investigations for clinical use are eagerly awaited.
KW - 3D surgical guide
KW - arrhythmias treatment
KW - biomaterial tests
KW - radiofrequency ablation
KW - thermal test
UR - http://www.scopus.com/inward/record.url?scp=85138872444&partnerID=8YFLogxK
U2 - 10.3389/fcvm.2022.978333
DO - 10.3389/fcvm.2022.978333
M3 - Article
C2 - 36186978
VL - 9
JO - Frontiers in cardiovascular medicine
JF - Frontiers in cardiovascular medicine
SN - 2297-055X
M1 - 978333
ER -