The gut microbiome in adult multiple sclerosis: exploring associations with disease course

Onderzoeksoutput: PhD Thesis

Samenvatting

Multiple sclerosis (MS) is a chronic, inflammatory, debilitating disease of the central nervous system (CNS), with the occurrence of demyelinating lesions in the brain, spinal cord and optic nerve as its pathological hallmark. The cause of MS is currently unknown, but different factors, both genetic and environmental, are thought to be involved in its etiology. Although recent animal research implicates the gut microbiota in MS pathology, previous studies with human cohorts have mostly investigated whether an imbalance of gut microbiota composition (also known as gut dysbiosis) is present in patients - but not if and how the gut microbiota is associated with MS disease course. In addition, important covariates of gut community composition (e.g. transit time) have not been addressed in the past, which hampers the identification of disease-specific signals. In this project, we will first assess the gut microbiome in MS while taking into account previously identified confounders. Then, using longitudinal studies, we will assess whether gut microbiota features may predict future disease course and how gut microbiota dynamics are affected by different MS treatments in recently diagnosed patients.
Originele taal-2English
KwalificatieDoctor in Medical Sciences
Toekennende instantie
  • KU Leuven
  • Vrije Universiteit Brussel
Begeleider(s)/adviseur
  • Raes, Jeroen, Promotor, Externe Persoon
  • D'Hooghe, Marie Beatrice, Co-Promotor
Datum van toekenning1 sep 2021
Plaats van publicatieBrussels
StatusPublished - 2021

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