The impact of combining low tube voltage scanning with iterative reconstruction on total iodine dose in coronary CT angiography.

Onderzoeksoutput: Meeting abstract (Book)Research


Purpose: To assess the impact of combining low-tube voltages and iterative reconstruction (IR) on contrast dose in coronary CTA.

Methods and Materials: A standard of care (SoC) 120kVp scan with 320mgI/ml iodine based contrast (Visipaque, GE Healthcare) and FBP reconstruction was compared with two study protocols: 80kVp with 160mgI/ml (protocol A) and 100kVp with 200mgI/ml (protocol B), both reconstructed with IR (ASiR). Each protocol was scanned (Discovery) three times on two minipigs (Ellegaard) with constant injection protocol (speed 3ml/s, volume 1.5ml/kg) and radiation dose. Quantitative image quality was evaluated by CT-value and signal-to-noise ratio (SNR) of the right coronary artery (RCA), left anterior descending coronary (LAD) and left circumflex artery (LCx). Expert readers performed qualitative assessment for overall quality, vessel sharpness, noise and streak artifacts.

Results: Despite reduced iodine load, both study protocols did not yield inferior CT-value and SNR for all arteries. For RCA, the mean SoC signal (307HU) was preserved with protocol A (273HU, p=0.15) and B (258HU, p=0.08). Also the SNR was non inferior from SoC (SNR=7.0) with A (8.1, p=0.75) and B (8.7, p=0.57). All scans were perceived to be of at least acceptable quality on all evaluated parameters allowing diagnostic interpretation. No statistical differences were observed (all p-values>0.12), except for streak artifacts (p=0.01) who were considered to be more severe, although acceptable, with protocol A.

Conclusion: The use of a reduced tube voltage combined with iterative reconstruction allows a marked reduction in iodine dose up to a factor of two without impairing image quality.
Originele taal-2English
TitelEuropean Congress of Radiology (ECR), Vienna, March
StatusPublished - mrt 2014
EvenementEuropean Congress of Radiology, ECR 2014 - Vienna, Austria
Duur: 6 mrt 201410 mrt 2014


ConferenceEuropean Congress of Radiology, ECR 2014


Duik in de onderzoeksthema's van 'The impact of combining low tube voltage scanning with iterative reconstruction on total iodine dose in coronary CT angiography.'. Samen vormen ze een unieke vingerafdruk.

Citeer dit