The impact of optimized mRNA on cancer vaccination

Wout De Mey; Quentin Lecocq; Dorien Autaers; Karine Breckpot; Kris Thielemans; Lorenzo Franceschini

Samenvatting

Messenger RNA (mRNA) based therapeutics have been in the last 10 years extensively exploited as attractive treatment against cancer. However, in vivo delivery of in vitro transcribed (IVT) mRNA can cause rapid production of type I interferon and trigger a counteracting effect. On one hand a strong innate immune response in induced, on the other this is know to reduce mRNA translation and thus possibly decrease the mRNA vaccine efficiency. Here, we enhanced mRNA biological activity improving mRNA translatability in the cell and lowering the in-vivo molecular immunogenicity.

Originele taal-2	English
Pagina's	1
Aantal pagina's	1
Status	Published - 7 feb. 2020
Evenement	BACR Annual Meeting 2020: Cancer metastasis: From bedside to bench - Vrije Universiteit Brussel, Campus Jette, Brussels, Belgium Duur: 7 feb. 2020 → 7 feb. 2020 Congresnummer: 26th https://www.bacr.be/program/

Conference

Conference	BACR Annual Meeting 2020
Land/Regio	Belgium
Stad	Brussels
Periode	7/02/20 → 7/02/20
Internet adres	https://www.bacr.be/program/

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BACR_ABSTRACT_Wout de Mey_FinalFinal published version, 16,9 KBLicentie: Unspecified

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Permanente koppeling

VOPPU95: VOPPU95 - Prijs Kankeronderzoek - Wout De Mey
Breckpot, K. (Administrative Promotor), Thielemans, K. (Co-Promoter) & de Mey, W. (Mandataris)
1/01/21 → 30/06/21
Project: Fundamenteel
SRP48: Strategic Research Programme: Cancer Cell Targeting in Myeloma and Melanoma (MyMe)
Vanderkerken, K. (Administrative Promotor), Thielemans, K. (Administrative Promotor), Vanderkerken, K. (Co-Promoter) & Breckpot, K. (Co-Promoter)
1/11/17 → 31/10/24
Project: Fundamenteel

Citeer dit

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title = "The impact of optimized mRNA on cancer vaccination",

abstract = "Messenger RNA (mRNA) based therapeutics have been in the last 10 years extensively exploited as attractive treatment against cancer. However, in vivo delivery of in vitro transcribed (IVT) mRNA can cause rapid production of type I interferon and trigger a counteracting effect. On one hand a strong innate immune response in induced, on the other this is know to reduce mRNA translation and thus possibly decrease the mRNA vaccine efficiency. Here, we enhanced mRNA biological activity improving mRNA translatability in the cell and lowering the in-vivo molecular immunogenicity.",

keywords = "mRNA, Cancer, Immunotherapy",

author = "\{De Mey\}, Wout and Quentin Lecocq and Dorien Autaers and Karine Breckpot and Kris Thielemans and Lorenzo Franceschini",

year = "2020",

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language = "English",

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note = "BACR Annual Meeting 2020 : Cancer metastasis: From bedside to bench ; Conference date: 07-02-2020 Through 07-02-2020",

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TY - CONF

T1 - The impact of optimized mRNA on cancer vaccination

AU - De Mey, Wout

AU - Lecocq, Quentin

AU - Autaers, Dorien

AU - Breckpot, Karine

AU - Thielemans, Kris

AU - Franceschini, Lorenzo

N1 - Conference code: 26th

PY - 2020/2/7

Y1 - 2020/2/7

N2 - Messenger RNA (mRNA) based therapeutics have been in the last 10 years extensively exploited as attractive treatment against cancer. However, in vivo delivery of in vitro transcribed (IVT) mRNA can cause rapid production of type I interferon and trigger a counteracting effect. On one hand a strong innate immune response in induced, on the other this is know to reduce mRNA translation and thus possibly decrease the mRNA vaccine efficiency. Here, we enhanced mRNA biological activity improving mRNA translatability in the cell and lowering the in-vivo molecular immunogenicity.

AB - Messenger RNA (mRNA) based therapeutics have been in the last 10 years extensively exploited as attractive treatment against cancer. However, in vivo delivery of in vitro transcribed (IVT) mRNA can cause rapid production of type I interferon and trigger a counteracting effect. On one hand a strong innate immune response in induced, on the other this is know to reduce mRNA translation and thus possibly decrease the mRNA vaccine efficiency. Here, we enhanced mRNA biological activity improving mRNA translatability in the cell and lowering the in-vivo molecular immunogenicity.

KW - mRNA

KW - Cancer

KW - Immunotherapy

M3 - Unpublished abstract

SP - 1

T2 - BACR Annual Meeting 2020

Y2 - 7 February 2020 through 7 February 2020

ER -

The impact of optimized mRNA on cancer vaccination

Samenvatting

Conference

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Projecten

VOPPU95: VOPPU95 - Prijs Kankeronderzoek - Wout De Mey

SRP48: Strategic Research Programme: Cancer Cell Targeting in Myeloma and Melanoma (MyMe)

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