The influence of non-invasive brain stimulation on stress responses as a function of personality

S. De Witte, M. Pulopulos, M.A. Vanderhasselt, R. De Raedt, J. Schiettecatte, E. Anckaert, A. Salvador, C. Baeken

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Question: The potential of personalized protocols to optimize the clinical efficacy of non-invasive brain stimulation (NIBS) techniques has increasingly gained attention. For example, in stress-related disorders, personality characteristics may influence the clinical outcome of NIBS, such as intermittent theta-burst stimulation (iTBS). However, the underlying physiological mechanisms as to how personality may affect the iTBS response to stress remains to be clarified. Methods: Previous studies show that non-invasive brain stimulation over the dorsolateral prefrontal cortex (DLPFC) can influence stress-responses. Therefore, in this sham-controlled crossover-design, two subsequent sessions of iTBS were administered over the left DLPFC to thirty-eight healthy-volunteers after a confrontation with a social-evaluative stressor, while mood and salivary cortisol were measured through the whole protocol. Furthermore, to take possible personality influences into account, participants completed the Temperament and Character Inventory (TCI). Results: Overall, two iTBS sessions did not influence mood or cortisol secretion. However, when taking into account personality features, higher scores on the character dimension Cooperativeness were related to decreased cortisol secretion, after active but not sham stimulation. Conclusion: Personality features may be of interest to explain individual responses to NIBS.
Originele taal-2English
Pagina's (van-tot)173
Aantal pagina's1
TijdschriftClinical Neurophysiology
Volume131
Nummer van het tijdschrift4
DOI's
StatusPublished - 1 apr 2020

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