The Role of Functional Amyloids in Bacterial Virulence

Nani Van Gerven, Sander E Van der Verren, Dirk M Reiter, Han Remaut

Onderzoeksoutput: Scientific reviewpeer review

89 Citaten (Scopus)


Amyloid fibrils are best known as a product of human and animal protein misfolding disorders, where amyloid formation is associated with cytotoxicity and disease. It is now evident that for some proteins, the amyloid state constitutes the native structure and serves a functional role. These functional amyloids are proving widespread in bacteria and fungi, fulfilling diverse functions as structural components in biofilms or spore coats, as toxins and surface-active fibers, as epigenetic material, peptide reservoirs or adhesins mediating binding to and internalization into host cells. In this review, we will focus on the role of functional amyloids in bacterial pathogenesis. The role of functional amyloids as virulence factor is diverse but mostly indirect. Nevertheless, functional amyloid pathways deserve consideration for the acute and long-term effects of the infectious disease process and may form valid antimicrobial targets.

Originele taal-2English
Pagina's (van-tot)3657-3684
Aantal pagina's28
TijdschriftJournal of Molecular Biology
Nummer van het tijdschrift20
Vroegere onlinedatum12 jul 2018
StatusPublished - 12 okt 2018


Duik in de onderzoeksthema's van 'The Role of Functional Amyloids in Bacterial Virulence'. Samen vormen ze een unieke vingerafdruk.

Citeer dit