The role of inflammaging and advanced glycation end products on paratonia in patients with dementia

Hans Drenth, Sytse Zuidema, Ivan Bautmans, Hans Hobbelen

Onderzoeksoutput: Article

Samenvatting

Impaired motor function is a prominent characteristic of aging. Inflammatory processes and oxidative stress from advanced glycation end-products are related to impaired motor function and could plausibly be a contributing factor to the pathogenesis of paratonia, a specific motor disorder in people with dementia. Severe paratonia results in a substantial increase of a caretaker's burden and a decrease in the quality of life. The pathogenesis of paratonia is not well understood, and no effective interventions are available to combat it. Intensive glycaemic control, reducing oxidative stress, possibly combined with a low AGE diet and AGE targeting medication may be the key method for preventing advanced glycation end-product accumulation and reducing the inflammatory burden as well as possibly postponing or preventing paratonia.

Originele taal-2English
Artikelnummer111125
Aantal pagina's5
TijdschriftExperimental Gerontology
Volume142
DOI's
StatusPublished - dec 2020

Bibliografische nota

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

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