Background The inconsistent association of patient-reported Multiple Sclerosis Neuropsychological Questionnaire (MSNQ) scores with performance-based cognitive tests in MS could be related to the degree of disability, due to certain MSNQ-questions assuming some self-dependence and intact instrumental ADLs.

Objectives To test whether the relation between subjective and objective cognitive performance could be moderated by physical disability as measured by the Expanded Disability Status Scale (EDSS), we assessed the correlation between MSNQ and Symbol Digit Modalities Test (SDMT) scores in different EDSS groups.

Methods From 288 MS patients who completed the patient-report MSNQ and a two‐question screening tool for depression, we also collected SDMT and EDSS scores. We analysed correlations in the total group and three EDSS subgroups: Low 0.0 – 3.0, Medium 3.5 – 6.0 and High 6.5 – 9.5.

Results We found a significant and negative correlation between patient-reported MSNQ scores and SDMT scores in the low EDSS (r = -.225, p = .044), but not in the medium and high EDSS groups, and significant positive correlations between MSNQ and depression in all subgroups.

Conclusions Our data suggest that the patient-report MSNQ has potential as a measure of cognition in patients with low EDSS-scores but not in the medium and high EDSS ranges.
Originele taal-2English
StatusPublished - 3 feb 2021


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