Samenvatting
In vivo administration of the phenothiazine drug, thioridazine, inhibits hepatic peroxisomal beta-oxidation in mice. In starving animals, 3-hydroxybutyrate concentration is not decreased by thioridazine treatment. These results provide the first demonstration of thioridazine as a selective inhibitor of peroxisomal beta-oxidation in intact animals. Thioridazine might supply a tool for simulation of pathological conditions in which peroxisomal beta-oxidation is impaired.
| Originele taal-2 | English |
|---|---|
| Pagina's (van-tot) | 331-333 |
| Aantal pagina's | 3 |
| Tijdschrift | FEBS Letters |
| Volume | 187 |
| Status | Published - 1985 |