Thymosin {beta}4 has tumor suppressive effects and its decreased expression results in poor prognosis and decreased survival in multiple myeloma.

Jo Caers, D. Hose, Ine Kuipers, Tomas Bos, Els Van Valckenborgh, Eline Menu, Elke De Bruyne, Hartmut Goldschmidt, Benjamin Van Camp, Bernard Klein, Karin Vanderkerken

Onderzoeksoutput: Article

15 Citaten (Scopus)

Samenvatting

Thymosin beta 4 (Tbeta4) is a polypeptide involved in cellular proliferation, differentiation, and migration, overexpressed in several tumor-entities. We evaluated its expression and function in 298 newly diagnosed multiple-myeloma patients and the murine 5TMM model. Mean-Tbeta4-expression was significantly lower in myeloma cells compared to normal plasma cells (p
Originele taal-2English
Pagina's (van-tot)163-167
Aantal pagina's5
TijdschriftHaematologica
Volume95
Vroegere onlinedatum14 okt 2009
DOI's
StatusPublished - jan 2010

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