Time-course of contrast enhancement in spleen and liver with Exia 160, Fenestra LC, and VC

Inneke Willekens; Tony Lahoutte; Nico Buls; Christian Vanhove; Rudi Deklerck; Axel Bossuyt; Johan de Mey

doi:10.1007/s11307-008-0186-8

Time-course of contrast enhancement in spleen and liver with Exia 160, Fenestra LC, and VC

Inneke Willekens, Tony Lahoutte, Nico Buls, Christian Vanhove, Rudi Deklerck, Axel Bossuyt, Johan de Mey

Onderzoeksoutput: Article › peer review

65 Citaten (Scopus)

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OBJECTIVE: The purpose of this study was to compare the time-course of contrast-enhancement in spleen and liver using Exia 160 in comparison with Fenestra LC and VC in healthy mice.

PROCEDURES: Healthy C57bl/6 mice were used in this study. Fenestra LC and VC was administered intravenously at a dose of 0.1 ml/20 g or 0.2 ml/20 g. Exia 160 at a dose of 0.05 ml/20 g or 0.1 ml/20 g. Each animal underwent a micro-CT scan before contrast injection (baseline) and immediately after contrast injection. Additional scans were performed at 1, 2, 3, 4, 24, and 48 h after contrast administration. The mice who received Exia 160 were also scanned after 15, 30, and 45 min.

RESULTS: The peak enhancement of Exia 160 occurred after 15 min for the spleen and after 30 min for the liver.

CONCLUSIONS: Exia 160 allows rapid spleen and liver enhancement. The high iodine content results in small injection volumes.

Originele taal-2	English
Pagina's (van-tot)	128-135
Aantal pagina's	8
Tijdschrift	Mol Imaging Biol
Volume	11
Nummer van het tijdschrift	2
DOI's	https://doi.org/10.1007/s11307-008-0186-8
Status	Published - 11 dec. 2008

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title = "Time-course of contrast enhancement in spleen and liver with Exia 160, Fenestra LC, and VC",

abstract = "OBJECTIVE: The purpose of this study was to compare the time-course of contrast-enhancement in spleen and liver using Exia 160 in comparison with Fenestra LC and VC in healthy mice.PROCEDURES: Healthy C57bl/6 mice were used in this study. Fenestra LC and VC was administered intravenously at a dose of 0.1 ml/20 g or 0.2 ml/20 g. Exia 160 at a dose of 0.05 ml/20 g or 0.1 ml/20 g. Each animal underwent a micro-CT scan before contrast injection (baseline) and immediately after contrast injection. Additional scans were performed at 1, 2, 3, 4, 24, and 48 h after contrast administration. The mice who received Exia 160 were also scanned after 15, 30, and 45 min.RESULTS: The peak enhancement of Exia 160 occurred after 15 min for the spleen and after 30 min for the liver.CONCLUSIONS: Exia 160 allows rapid spleen and liver enhancement. The high iodine content results in small injection volumes.",

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author = "Inneke Willekens and Tony Lahoutte and Nico Buls and Christian Vanhove and Rudi Deklerck and Axel Bossuyt and {de Mey}, Johan",

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T1 - Time-course of contrast enhancement in spleen and liver with Exia 160, Fenestra LC, and VC

AU - Willekens, Inneke

AU - Lahoutte, Tony

AU - Buls, Nico

AU - Vanhove, Christian

AU - Deklerck, Rudi

AU - Bossuyt, Axel

AU - de Mey, Johan

PY - 2008/12/11

Y1 - 2008/12/11

N2 - OBJECTIVE: The purpose of this study was to compare the time-course of contrast-enhancement in spleen and liver using Exia 160 in comparison with Fenestra LC and VC in healthy mice.PROCEDURES: Healthy C57bl/6 mice were used in this study. Fenestra LC and VC was administered intravenously at a dose of 0.1 ml/20 g or 0.2 ml/20 g. Exia 160 at a dose of 0.05 ml/20 g or 0.1 ml/20 g. Each animal underwent a micro-CT scan before contrast injection (baseline) and immediately after contrast injection. Additional scans were performed at 1, 2, 3, 4, 24, and 48 h after contrast administration. The mice who received Exia 160 were also scanned after 15, 30, and 45 min.RESULTS: The peak enhancement of Exia 160 occurred after 15 min for the spleen and after 30 min for the liver.CONCLUSIONS: Exia 160 allows rapid spleen and liver enhancement. The high iodine content results in small injection volumes.

AB - OBJECTIVE: The purpose of this study was to compare the time-course of contrast-enhancement in spleen and liver using Exia 160 in comparison with Fenestra LC and VC in healthy mice.PROCEDURES: Healthy C57bl/6 mice were used in this study. Fenestra LC and VC was administered intravenously at a dose of 0.1 ml/20 g or 0.2 ml/20 g. Exia 160 at a dose of 0.05 ml/20 g or 0.1 ml/20 g. Each animal underwent a micro-CT scan before contrast injection (baseline) and immediately after contrast injection. Additional scans were performed at 1, 2, 3, 4, 24, and 48 h after contrast administration. The mice who received Exia 160 were also scanned after 15, 30, and 45 min.RESULTS: The peak enhancement of Exia 160 occurred after 15 min for the spleen and after 30 min for the liver.CONCLUSIONS: Exia 160 allows rapid spleen and liver enhancement. The high iodine content results in small injection volumes.

KW - Animals

KW - Contrast Media

KW - Image Processing, Computer-Assisted

KW - Liver

KW - Male

KW - Metabolic Clearance Rate

KW - Mice

KW - Mice, Inbred C57BL

KW - Nonlinear Dynamics

KW - Spleen

KW - Time Factors

KW - X-Ray Microtomography

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DO - 10.1007/s11307-008-0186-8

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SN - 1536-1632

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EP - 135

JO - Mol Imaging Biol

JF - Mol Imaging Biol

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ER -

Time-course of contrast enhancement in spleen and liver with Exia 160, Fenestra LC, and VC

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