Towards spatial comprehensive three-dimensional liquid chromatography: A tutorial review

Thomas Themelis, Ali Amini, Jelle De Vos, Sebastiaan Eeltink

Onderzoeksoutput: Articlepeer review

17 Citaten (Scopus)
134 Downloads (Pure)

Samenvatting

In spatial comprehensive three-dimensional chromatography (3D-LC) components are separated within a three-dimensional separation space that can lead to unprecedented resolving power, in terms of peak capacity and peak-production rate. The maximum peak capacity is the product of the peak capacities achieved in the individual dimensions when orthogonal retention mechanisms are incorporated. The parallel development of the second- and third-dimension separation stages overcomes the fundamental limitation of conventional multi-dimensional approaches, in which sampled fractions are analyzed sequentially. General considerations for chip design are discussed and possibilities and prospects to establish spatial comprehensive 3D-LC analysis are presented.

Originele taal-2English
Artikelnummer238157
TijdschriftAnalytica Chimica Acta
Volume1148
DOI's
StatusPublished - 1 mrt 2021

Bibliografische nota

Publisher Copyright:
© 2020 Elsevier B.V.

Vingerafdruk

Duik in de onderzoeksthema's van 'Towards spatial comprehensive three-dimensional liquid chromatography: A tutorial review'. Samen vormen ze een unieke vingerafdruk.

Citeer dit