@inproceedings{305bab200550454d8ac76d583a93ff54,
title = "Trait Interindividual Differences in the Effectiveness of Modafinil.",
abstract = "Purpose: To optimize the usage of modafinil as a cognitive enhancer and increase safety and effectiveness, we sought to assess the trait-characteristic of modafinil-sensitivity. Methods: 11 healthy participants (age = 21 ± 2 yr) were tested on 2 separate occasions during which they were sleep deprived for one night. During one trial they received 2 × 200 mg modafinil (i.e. EXP); during the other they received 2 × a placebo-capsule (i.e. CON). Physiological (e.g. heart rate and blood pres-sure), subjective (e.g. sleepiness and mood state) and behavioral (e.g. psychomotor vigilance task) measures of sleep-wake regulation were followed up. Results: Both PVT performance and perceived sleepiness were significantly improved in EXP at 2AM and 4AM during the sleep deprivation-night, compared to in CON. Additionally, an ICC of 0.90 for the delta (CON – EXP) in non-adjusted reaction time was observed. Conclusion: Stable and robust interindividual differences in modafinil-sensitivity are clearly present across day and night.",
author = "{Van Cutsem}, Jeroen and Emilie Dessy and {Van Puyvelde}, Martine and Olivier Mairesse and {Xavier Neyt}, {Royal Military Academy, Brussels} and Nathalie Pattyn",
year = "2021",
doi = "10.1007/978-3-030-80288-2_2",
language = "English",
isbn = "9783030802875",
series = "Lecture Notes in Networks and Systems",
publisher = "International Conference on Applied Human Factors and Ergonomics ",
pages = "12--20",
editor = "Arezes, {Pedro M.} and Boring, {Ronald L.}",
booktitle = "Proceedings of the AHFE 2021 Virtual Conferences on Safety Management and Human Factors, and Human Error, Reliability, Resilience, and Performance",
}